Role of endogenous brain-derived neurotrophic factor and sortilin in B cell survival

The Journal of Immunology : Official Journal of the American Association of Immunologists
Anne-Laure FauchaisMarie-Odile Jauberteau

Abstract

Brain-derived neurotrophic factor (BDNF), a major neuronal growth factor, is also known to exert an antiapoptotic effect in myeloma cells. Whereas BDNF secretion was described in B lymphocytes, the ability of B cells to produce sortilin, its transport protein, was not previously reported. We studied BDNF production and the expression of its receptors, tyrosine protein kinase receptor B and p75 neurotrophin receptor in the human pre-B, mature, and plasmacytic malignant B cell lines under normal and stress culture conditions (serum deprivation, Fas activation, or their combination). BDNF secretion was enhanced by serum deprivation and exerted an antiapoptotic effect, as demonstrated by neutralization experiments with antagonistic Ab. The precursor form, pro-BDNF, also secreted by B cells, decreases under stress conditions in contrast to BDNF production. Stress conditions induced the membranous expression of p75 neurotrophin receptor and tyrosine protein kinase receptor B, maximal in mature B cells, contrasting with the sequestration of both receptors in normal culture. By blocking Ab and small interfering RNA, we evidenced that BDNF production and its survival function are depending on sortilin, a protein regulating neurotrophin ...Continue Reading

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Nov 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eva ReuterFrauke Zipp
Jan 23, 2019·Frontiers in Pharmacology·Hugo TalbotMarie-Odile Jauberteau
Mar 4, 2020·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Aihua LiuLihua Liu
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