Role of endogenous gamma interferon in host response to infection with blood-stage Plasmodium chabaudi AS.

Infection and Immunity
Mary M StevensonJ E Podoba

Abstract

The role of gamma interferon (IFN-gamma), a pluripotent lymphokine capable of activating macrophages, in acquired immunity to blood-stage malaria was investigated. C57BL-derived, lipopolysaccharide-resistant C57BL/10ScN mice, which were found to be resistant to intraperitoneal (i.p.) infection with 10(6) Plasmodium chabaudi AS parasitized erythrocytes, were treated with monoclonal anti-IFN-gamma antibody (MAb). Two MAbs were used: R4-6A2, a rat anti-mouse, neutralizing immunoglobulin G1, which was prepared against natural murine IFN-gamma, and DB-1, a murine anti-rat immunoglobulin G1 prepared against recombinant rat IFN-gamma, which can neutralize the murine molecule as well as the rat molecule. C57BL/10ScNH mice were injected i.p. with 200 micrograms of R4-6A2 1 day before infection and every 3 days through day 21. Control mice were treated with normal rat serum. In separate experiments, DB-1 (1.0 mg per week for 4 weeks) was administered i.p. to C57BL/10ScNH mice beginning on the day of infection; control mice were untreated. Control and MAb-treated mice were infected i.p. with 10(6) P. chabaudi AS parasitized erythrocytes, and the course and outcome of infection were determined. Control mice exhibited a course of infection ...Continue Reading

References

Jun 1, 1986·The Journal of General Virology·P H van der MeideH Schellekens
Nov 13, 1989·Journal of Immunological Methods·N Van Rooijen
Sep 1, 1989·Parasite Immunology·M M StevensonJ E Podoba
Dec 1, 1989·Immunological Reviews·J LanghorneS S Gillard
Feb 12, 1987·The New England Journal of Medicine·B Beutler, A Cerami
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N A Buchmeier, R D Schreiber
Jan 1, 1984·Annual Review of Immunology·E R Unanue
Oct 1, 1982·Infection and Immunity·M M StevensonE Skamene

❮ Previous
Next ❯

Citations

Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhong Su, Mary M Stevenson
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rosa M EliasMaria Regina D'Império Lima
Aug 27, 2014·Mediators of Inflammation·Sin Yee GunLaurent Rénia
Sep 16, 2020·Nature Communications·Larissa M N PereiraRicardo T Gazzinelli
Feb 13, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Karina R B BastosMaria Regina D'Império Lima
Dec 19, 2007·Parasite Immunology·A L LeisewitzD Kwiatkowski
Nov 2, 2019·Immunological Reviews·Rajiv KumarChristian R Engwerda
Jan 1, 1994·Biotherapy·W M Eling, P G Kremsner
Dec 1, 1993·Scandinavian Journal of Immunology·J LanghorneK Eichmann
Jun 12, 2002·Genes and Immunity·A FortinP Gros
May 29, 2010·The Journal of Biological Chemistry·Leon GrayferMiodrag Belosevic
Sep 2, 2005·American Journal of Human Biology : the Official Journal of the Human Biology Council·Michael P Muehlenbein, Richard G Bribiescas
Sep 30, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katherine LabbéMaya Saleh
Mar 2, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sandra Marcia MuxelMaria Regina D'Império Lima
Dec 23, 2011·Journal of Biomedicine & Biotechnology·Mamoru NiikuraFumie Kobayashi
Dec 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana Paula Freitas do RosárioMaria Regina D'Império Lima
Nov 19, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kelly M CautivoAlexis M Kalergis
Jul 20, 2007·Scandinavian Journal of Immunology·S I Castillo-MéndezM R D'Império Lima
Jul 9, 2010·Journal of Leukocyte Biology·Matthew B B McCall, Robert W Sauerwein
Jun 13, 2018·Frontiers in Immunology·Leon GrayferMiodrag Belosevic
Dec 8, 2020·Clinical & Translational Immunology·Simon H ApteDenise L Doolan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.