Role of endogenous nitric oxide in the brain stem on the rapid adaptation of baroreflex

Hypertension
K HironagaA Takeshita

Abstract

It has been shown that nitric oxide in the brain stem plays an important role in the control of sympathetic nerve activity. We examined the role of endogenous nitric oxide in the brain stem in the rapid central adaptation of baroreflex control of sympathetic nerve activity in anesthetized rabbits. Bilateral carotid sinuses were isolated, and a stepwise increase in pressure of 25 or 50 mm Hg for 50 to 60 seconds was applied to the carotid sinuses while the arterial pressure and renal sympathetic nerve activity were recorded. The renal sympathetic nerve activity was inhibited by the stepwise increase in carotid sinus pressure, but thereafter it gradually returned toward the baseline level despite the fact that carotid sinus pressure was kept constant. This procedure was performed after intracisternal injection of N(omega)-nitro-L-arginine methyl ester (L-NAME, 8 micromol), N(omega)-nitro-D-arginine methyl ester (D-NAME, 8 micromol), L-arginine (40 micromol), or the vehicle solution. The magnitude of the immediate and maximal inhibition of renal sympathetic nerve activity caused by a stepwise increase in carotid sinus pressure was similar between the vehicle and L-NAME treatment, but the rate of recovery of the renal sympathetic n...Continue Reading

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Citations

Jul 17, 1999·Brain Research. Brain Research Reviews·T L Krukoff
Jan 23, 1999·Current Opinion in Nephrology and Hypertension·M Sander, R G Victor
Mar 11, 2004·Clinical and Experimental Pharmacology & Physiology·Wun-Chin Wu, Chok-Yung Chai
Jan 13, 2006·Clinical and Experimental Pharmacology & Physiology·Daryl O SchwenkeMikiyasu Shirai
May 8, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshitaka HirookaAkira Takeshita
Mar 10, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshitaka Hirooka
Dec 17, 2014·Journal of Neurotrauma·Jiří ŠedýJosef Zicha
Dec 16, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ana Carolina Rodrigues DiasSteven W Mifflin
Dec 18, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Scott A SmithJianhua Li
Jul 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Koji SakaiKenji Sunagawa
Aug 14, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jirí SedyEva Syková
May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura
Apr 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Jianhua Li
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Virginia L BrooksKathleen P O'Hagan
Sep 25, 2001·Experimental Biology and Medicine·K P PatelY Hirooka
Feb 4, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yoshitaka HirookaKenji Sunagawa
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·I MatsuoA Takeshita

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