Role of endogenous nitric oxide synthase inhibitor in gastric mucosal injury

Canadian Journal of Physiology and Pharmacology
Li WangYuan-Jian Li

Abstract

To explore the role of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA) in gastric mucosal injury, 3 models of gastric mucosal injury induced by ethanol, indomethacin, or cold stress were used in rats. The cultured human gastric mucosal epithelial cell line GES-1 infected by Helicobacter pylori (Hp) was selected to mimic human gastric mucosal injury. Gastric mucosal ulcer index (UI), levels of ADMA and NO, and activity of dimethylarginine dimethylaminohydrolase (DDAH) were determined in the mucosal injury models; in Hp-infected or ADMA-treated GES-1 cells, levels of ADMA, NO, and TNF-alpha and activity of DDAH were measured. The results showed that UI and levels of ADMA were markedly increased and accompanied by significantly decreased DDAH activity in the mucosal injury models. Incubation of GES-1 cells with Hp increased levels of TNF-alpha and ADMA and decreased activity of DDAH. Administration of ADMA also increased levels of TNF-alpha. The results suggest that ADMA plays an important role in facilitating gastric mucosal injury, an effect which is associated with inhibiting NO synthesis and inducing inflammatory reaction.

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Citations

Apr 10, 2013·Journal of Medicinal Food·Wei HeTao Wang
Jan 20, 2010·Clinical and Experimental Pharmacology & Physiology·J Michael ZinkievichRobert A Levine
Jan 24, 2014·PloS One·Germana Freire Rocha CaldasAlmir Gonçalves Wanderley
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Oct 9, 2008·Canadian Journal of Physiology and Pharmacology·Ying-Zi LiuYuan-Jian Li
Dec 18, 2008·Canadian Journal of Physiology and Pharmacology·Zhe ZhangYuan-Jian Li
Apr 1, 2009·Expert Opinion on Drug Metabolism & Toxicology·Carol Wadham, Arduino A Mangoni
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Aug 28, 2021·Biomolecules·Iwona Bednarz-MisaMałgorzata Krzystek-Korpacka

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