PMID: 12635504Mar 15, 2003Paper

Role of endogenous retroviruses in autoimmune diseases

Rheumatic Diseases Clinics of North America
Andras Perl

Abstract

Endogenous retroviruses (ERVs) correspond to the integrated proviral form of infectious retroviruses that are trapped within the genome by mutations. Endogenous retroviruses represent a key molecular link between the host genome and infectious viral particles. Proteins encoded by ERVs are recognized by antiviral immune responses and become targets of autoreactivity. Activation of ERVs, such as human ERV-K or a human T-cell lymphotropic virus-related endogenous sequence, may also mediate pathogenicity of Epstein-Barr virus. Endogenous retrovirus peptides can directly regulate immune responses. Thus, molecular mimicry and immunomodulation by ERVs may account for self-reactivity and abnormal T- and B-cell functions in autoimmune disorders.

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Citations

Sep 1, 2007·Nature Clinical Practice. Rheumatology·Bruce Richardson
Jul 21, 2010·Current Opinion in Rheumatology·Andras PerlPaul E Phillips
Mar 9, 2010·International Journal of Clinical Rheumatology·Lisa Francis, Andras Perl
Jul 31, 2007·Future Microbiology·Sunit Kumar Singh
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Norbert Bannert, Reinhard Kurth
Dec 17, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Byung-Hoon JeongYong-Sun Kim
Mar 3, 2007·Molecular and Cellular Probes·Ravi TandonRegina Hofmann-Lehmann
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Sep 24, 2014·Seminars in Arthritis and Rheumatism·Lawrence O Okong'oChristian Scott
Feb 3, 2009·Molecular Immunology·Natalia PetrakovaMaria Isaguliants
Jul 20, 2011·Seminars in Cutaneous Medicine and Surgery·Ser Ling Chua SerlingToby Maurer
Jan 1, 2006·Expert Review of Clinical Immunology·Antonina Dolei
Mar 29, 2008·Lupus·Manel Ramos-Casals
Dec 18, 2009·Autoimmunity·Andras Perl
Nov 3, 2009·Lupus·G Domenico Sebastiani, M Galeazzi
Sep 18, 2004·Clinical and Experimental Immunology·P N NelsonUNKNOWN Molecular Immunology Research Group
Aug 29, 2006·The Journal of Biological Chemistry·Gyorgy NagyAndras Perl
Jun 12, 2013·The Open Rheumatology Journal·Nicola TugnetPaul Nelson
Jan 26, 2011·Journal of the International AIDS Society·Filiberto Cedeno-LaurentJose R Trujillo

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