Role of endothelial glycocalyx in sliding friction at the catheter-blood vessel interface.

Scientific Reports
Chengxiong LinPrashant Kumar Sharma

Abstract

Catheterization is a common medical operation to diagnose and treat cardiovascular diseases. The blood vessel lumen is coated with endothelial glycocalyx layer (EGL), which is important for the permeability and diffusion through the blood vessels wall, blood hemodynamics and mechanotransduction. However EGL's role in catheter-blood vessel friction is not explored. We use a porcine aorta to mimic the blood vessel and a catheter loop was made to rub in reciprocating sliding mode against it to understand the role of catheter loop curvature, stiffness, normal load, sliding speed and EGL on the friction properties. Trypsin treatment was used to cause a degradation of the EGL. Decrease in catheter loop stiffness and EGL degradation were the strongest factors which dramatically increased the coefficient of friction (COF) and frictional energy dissipation at the aorta-catheter interface. Increasing sliding speed caused an increase but increase in normal load first caused a decrease and then an increase in the COF and frictional energy. These results provide the basic data for safety of operation and damage control during catheterization in patients with degraded EGL.

References

Feb 5, 1985·Journal of Molecular Biology·M LevittP S Stern
Oct 1, 1994·Veterinary Immunology and Immunopathology·D H Sachs
Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H Vink, B R Duling
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·C B Henry, B R Duling
Feb 22, 2001·Medical Engineering & Physics·G Dougherty, J Varro
Sep 11, 2002·Journal of Biomedical Materials Research·Rebecca A CaldwellMartine LaBerge
Jul 12, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Alina A ConstantinescuJos A E Spaan
Jan 6, 2004·American Journal of Physiology. Heart and Circulatory Physiology·A W Mulivor, H H Lipowsky
Jun 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Dirk BrueggerBernhard Friedrich Becker
Aug 30, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Mirella GouverneurHans Vink
Sep 9, 2005·Current Opinion in Lipidology·Max NieuwdorpErik S G Stroes
Jan 10, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Ivan Rubio-GayossoBrian R Duling
Feb 13, 2007·Biochemical and Biophysical Research Communications·Manolis Y PahakisJohn M Tarbell
Mar 22, 2007·Annual Review of Biomedical Engineering·Sheldon WeinbaumEdward R Damiano
Apr 10, 2007·Trends in Cardiovascular Medicine·Jurgen W Van TeeffelenHans Vink
Dec 13, 2007·Anesthesiology·Daniel ChappellBernhard F Becker
Nov 17, 2009·Medical & Biological Engineering & Computing·Sang Hyo WooJin Ho Cho
Mar 17, 2010·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·X Wang, M Q-H Meng
Jun 30, 2012·The Journal of Trauma and Acute Care Surgery·Sisse R Ostrowski, Pär I Johansson
Oct 26, 2013·The Journal of Trauma and Acute Care Surgery·Luciana N TorresIvo Torres Filho
Dec 26, 2013·The Journal of Trauma and Acute Care Surgery·Martin SillesenHasan B Alam
Dec 17, 2014·Critical Care : the Official Journal of the Critical Care Forum·Daniel ChappellMarkus Rehm
Dec 8, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Nick J KoningChrista Boer
Apr 14, 2016·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Ulf SchöttPeter Bentzer
Jul 9, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Sashka DimitrievskaLaura E Niklason
Aug 24, 2016·Heart·Prachi BhatnagarNick Townsend

❮ Previous
Next ❯

Software Mentioned

Matlab
ImageJ

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.