Role of endothelial lipase in atherosclerosis

Translational Research : the Journal of Laboratory and Clinical Medicine
Ji HuangZhao Li

Abstract

Endothelial lipase, which is a newly identified member of the lipase family, plays an important role in high-density lipoprotein metabolism, which catalyzes the hydrolysis of high-density lipoprotein phospholipids and facilitates the clearance of high-density lipoprotein from the circulation. In addition, inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta), upregulate endothelial lipase expression, and endothelial lipase also affects the expression of cytokines, which in turn play an important role in atherogenesis. Endothelial lipase expression has been associated with macrophages within human atherosclerotic lesions. However, an important challenge is to determine how endothelial lipase alters the progression of atherosclerosis. Although few data are available from human studies, it seems that plasma endothelial lipase levels in individuals with atherosclerosis might be higher than that measured in healthy individuals. Therefore, we believe that endothelial lipase might be a promising marker for atherosclerosis in clinical settings in the future.

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Citations

Jun 29, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Margery A ConnellyBruce P Damiano
Apr 26, 2019·Journal of Cellular Biochemistry·Ismail Zaki ElnaggarEman Ahmed Abdelaziz
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Feb 7, 2021·Microorganisms·Alison H HughesKatherine R Duncan
May 19, 2021·Scientific Reports·Manuela Gago-DominguezJ Esteban Castelao

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