Role of endothelium-derived metabolites of arachidonic acid in enhanced pulmonary artery contractions in female rabbits

Hypertension
Sandra L Pfister, W B Campbell

Abstract

Previous studies reported sex differences in production of endothelium-derived substances and suggested that these compounds may be involved in regulation of vascular tone under both normal and pathological conditions. The present study was designed to compare the effects of endothelium-dependent contractions in pulmonary artery vessels obtained from male and female rabbits. Rings of intrapulmonary arteries were suspended under isometric tension in oxygenated Krebs' buffer. In male rabbit pulmonary artery, arachidonic acid and methacholine elicited endothelium-dependent, concentration-related contractions (maximal contraction, 79 +/- 4% and 54 +/- 4% of the KCl contractions, respectively). In contrast, endothelium-dependent arachidonic acid- and methacholine-induced contractions were greater in female pulmonary arteries (maximal response, 113 +/- 7% and 101 +/- 6% of the KCl contractions, respectively). There was no difference in KCl-induced contractions in female and male pulmonary arteries (1.2 +/- 0.1 versus 1.3 +/- 0.1 g, respectively). In male rabbits, the vasoconstrictor responses to arachidonic acid and methacholine were inhibited by the cyclooxygenase inhibitor indomethacin. We have previously identified thromboxane A2 ...Continue Reading

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Citations

Jan 19, 2005·British Journal of Pharmacology·Paul M VanhoutteStefano Taddei
Apr 30, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sharath KandhiDong Sun
Dec 7, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Xin TangWilliam B Campbell
Mar 4, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Minga M Sellers, John N Stallone
Oct 27, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sharath KandhiDong Sun

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