PMID: 11903501Mar 21, 2002Paper

Role of endothelium in adenosine receptor-mediated vasorelaxation in hypertensive rats

Fundamental & Clinical Pharmacology
M FahimS J Mustafa

Abstract

The present study was designed to investigate the role of endothelium derived relaxing factor nitric oxide (NO) in adenosine A2 receptor mediated vasorelaxation in normotensive (WKY) and hypertensive (SHR) rat aortic ring preparations. Adenosine analogues, 2-chloroadenosine (CAD) and 5-ethylcarboxamidoadenosine (NECA) produced concentration-dependent (10(-9)-10(-4) M) relaxation in phenylephrine (1 x 10(-6) M) precontracted vascular rings, which was significantly shifted to the right in SHR compared to WKY rats. Endothelium removal attenuated CAD and NECA relaxation responses in both SHR and WKY and abolished the difference in relaxation between SHR and WKY vascular tissues. The relaxation response to CAD was antagonised by adenosine A2 receptor antagonist, 8-sulfophenyltheophylline (8-SPT, 50 x 10(-6) M). The antagonism by 8-SPT was lower in SHR as compared to WKY tissues. L-monomethylarginine (L-LMMA) (30 x 10(-6) M) significantly shifted the CAD relaxation to the right, which was reversed by the addition of L-arginine (100 x 10(-6) M) in both SHR and WKY rats. However, the rightward shift by L-NMMA was smaller in SHR compared to WKY vascular tissues. Vasorelaxation response to acetylcholine (1 x 10(-6) M) was significantly i...Continue Reading

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Citations

Sep 29, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Maryam Sharifi SanjaniS Jamal Mustafa
Apr 17, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Virginia H HuxleyIngrid H Sarelius
Apr 6, 2005·The Journal of Pharmacy and Pharmacology·Teresa SousaAntónio Albino-Teixeira
May 27, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Alexander ZipprichRoberto J Groszmann
May 15, 2016·American Journal of Obstetrics and Gynecology·Robyn P RobertsMonica Longo
Aug 2, 2016·Biological & Pharmaceutical Bulletin·Shun WatanabeTsuneo Kobayashi
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
Jan 1, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Monica LongoGeorge R Saade
Aug 22, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Habib R AnsariS Jamal Mustafa
Jul 14, 2021·Microvascular Research·Marina GaetaBasmah Safdar

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