Role of endothelium in control of forearm blood flow in patients with heart failure

Journal of Cardiac Failure
A TakeshitaT Imaizumi

Abstract

We studied the role of endothelium in control of forearm blood flow during reactive and exercise hyperemia in patients with heart failure as well as in normal subjects. First, endothelium-dependent forearm vasodilation in response to acetylcholine (ACh), substance P, and endothelium-independent forearm vasodilation in response to sodium nitroprusside (SNP) were examined in patients with heart failure and in normal subjects. Endothelium-dependent forearm vasodilation in response to ACh but not to substance P was impaired in patients with heart failure. Endothelium-independent forearm vasodilation to SNP was also preserved in patients with heart failure. Second, the role of nitric oxide (NO) in reactive hyperemia and exercise hyperemia was examined in normal subjects using NG-monomethyl-L-arginine (L-NMMA), a blocker of NO synthesis. Results suggest that NO plays a minimal role in peak reactive hyperemia and exercise hyperemia in normal human forearm vessels. Finally, we determined if L-arginine, a precursor of NO, improves impaired endothelium-dependent vasodilation due to ACh and reactive and exercise hyperemia in patients with heart failure. L-Arginine augmented impaired ACh-induced vasodilation as well as reactive and exercis...Continue Reading

References

Nov 1, 1994·Circulation·T TagawaA Takeshita

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Citations

Jan 27, 1998·Current Opinion in Nephrology and Hypertension·A J Maxwell, J P Cooke
Mar 22, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Amilton C SantosCarlos E Negrão

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