Role of enteric nerves in immune-mediated changes in protease-activated receptor 2 effects on gut function.

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Terez Shea-DonohueAiping Zhao

Abstract

Protease-activated receptors (PARs) are expressed on structural and immune cells. Control of initiation, duration, and magnitude of PAR effects is linked to the level of receptor expression, availability of proteases, and the intracellular signal transduction machinery. We investigated nematode infection-induced changes in PAR(2) expression and the impact on smooth muscle and epithelial responses to PAR(2) agonists. Smooth muscle and epithelial cell function were assessed in wild-type, and IL-4, IL-13 or STAT6 gene-deficient mice following treatment with vehicle, Nippostrongylus brasiliensis or Heligmosomoides polygyrus, or IL-13. The role of enteric nerves was determined using tetrodotoxin to block nerve conduction. Expression of PAR(2) was assessed by real-time PCR, western blot and immunohistochemistry. Nematode infection induced a STAT6- and IL-13-dependent up-regulation of PAR(2) mRNA expression. The infection-induced hypercontractility to PAR(2) agonists required STAT6/IL-13 and was neurally mediated. In contrast, the infection-induced decrease in epithelial secretion to PAR(2) agonists was partly dependent on STAT6 and independent of enteric nerves. The hyposecretion was correlated with decreased PAR(2) immunofluorescent...Continue Reading

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Citations

Oct 12, 2012·Seminars in Immunopathology·Lisa A ReynoldsRick M Maizels
Dec 22, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Zhonghan YangAiping Zhao
Aug 23, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T Shea-DonohueA Zhao
Mar 25, 2014·Research in Veterinary Science·Augusta ZannoniNoemi Romagnoli
Mar 19, 2014·Gut Microbes·Terez Shea-DonohueToni M Antalis
Feb 18, 2011·Gut Microbes·Terez Shea-DonohueAiping Zhao
Feb 25, 2017·Parasite Immunology·T Shea-DonohueA Smith
Sep 1, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F SouffletM Neunlist
May 1, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aiping ZhaoTerez Shea-Donohue
Dec 15, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Joan Antoni Fernández-BlancoPatri Vergara
Jun 6, 2021·Molecular & Cellular Proteomics : MCP·David A Skerrett-ByrneJohn E Schjenken

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