Role of epidermal growth factor in the acquisition of ovarian steroid hormone responsiveness in the normal mouse mammary gland

Journal of Cellular Physiology
D P AnkrappS Z Haslam

Abstract

The purpose of the present studies was to investigate the role of epidermal growth factor (EGF) in the acquisition of estrogen (E) and progestin (P) responsiveness in the mouse mammary gland in vivo. Using the Elvax 40P implant technique to introduce bioactive molecules directly into the mammary gland to produce a localized effect, we have made the novel observation that EGF implanted into glands of pubertal mice followed by E treatment resulted in the precocious acquisition of E-inducible progesterone receptors (PR). In sexually mature mice, EGF implants alone were able to increase PR. A neutralizing antibody specific for EGF blocked E-dependent stimulation of end-bud development and PR induction. Furthermore, the antiestrogen ICI 182,780 blocked the EGF-induced stimulation end-buds and PR induction, indicating that these EGF effects are mediated via estrogen receptors (ER). Immunohistochemical analysis showed that the endogenous EGF content of mammary glands of mature mice was higher than pubertal mice, that E implants caused a localized increase in mammary gland EGF content in both pubertal and mature mice, and that in mature mice E caused an increase in stromal cell EGF content. We have previously shown that the acquisition...Continue Reading

References

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Citations

Mar 19, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Walter ImagawaHongzheng Zhang
Nov 10, 2001·Trends in Endocrinology and Metabolism : TEM·L Altucci, H Gronemeyer
Feb 22, 2001·Annual Review of Physiology·K Pettersson, J A Gustafsson
Dec 17, 2008·Women's Health·Carol A Lange, Douglas Yee
Oct 30, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Carol A Lange
Aug 30, 2005·Trends in Endocrinology and Metabolism : TEM·Robert X-D SongRichard J Santen
Sep 26, 2013·Matrix Biology : Journal of the International Society for Matrix Biology·Spyros S SkandalisNikos K Karamanos
Mar 31, 2006·Biology of Reproduction·Robert X-D Song, Richard J Santen
Jun 16, 1999·Endocrine Reviews·J F Couse, K S Korach
Jul 19, 2001·The Journal of Biological Chemistry·J M HallK S Korach
Dec 20, 2008·Endocrinology·Jörg IsenseePatricia Ruiz Noppinger
Feb 13, 2001·Microscopy Research and Technique·G B Silberstein
Sep 19, 2008·Biology of Reproduction·Christiane OttoKarl-Heinrich Fritzemeier
May 17, 2006·Journal of Dairy Science·F Y WuY K Cheng

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