Role of Epigenetics in Cardiac Development and Congenital Diseases

Physiological Reviews
Thomas Moore-MorrisMichel Puceat

Abstract

The heart is the first organ to be functional in the fetus. Heart formation is a complex morphogenetic process regulated by both genetic and epigenetic mechanisms. Congenital heart diseases (CHD) are the most prominent congenital diseases. Genetics is not sufficient to explain these diseases or the impact of them on patients. Epigenetics is more and more emerging as a basis for cardiac malformations. This review brings the essential knowledge on cardiac biology of development. It further provides a broad background on epigenetics with a focus on three-dimensional conformation of chromatin. Then, we summarize the current knowledge of the impact of epigenetics on cardiac cell fate decision. We further provide an update on the epigenetic anomalies in the genesis of CHD.

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Citations

Jul 4, 2019·Circulation Research·Rosibel J Mason, Thomas M Vondriska
Jul 10, 2020·Clinical Science·Yanxia QianJunhong Wang
Mar 21, 2020·Current Cardiology Reports·Carolin Rommel, Lutz Hein
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Methods Mentioned

BETA
transgenic
sumoylation
histone acetylation
acetylation
electron microscopy
super resolution nanoscopy
Hi-C
immunoprecipitation
DamID

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