PMID: 8592096Jan 1, 1996Paper

Role of epinephrine-induced hypokalemia in the regulation of renin and aldosterone in humans

The Journal of Laboratory and Clinical Medicine
R E KollochK O Stumpe

Abstract

Circulating epinephrine induces both stimulation of plasma renin activity (PRA) and a decrease in serum potassium concentration. This study was designed to determine the dose-response effects of systemic epinephrine infusion on the relationship of PRA and plasma aldosterone concentration. Twenty-one men with normal blood pressure received either an intravenous infusion of epinephrine at 12.5, 25, and 50 ng/(kg x min) by stepwise increments for 1 hour each or isotonic saline solution. Infusion of epinephrine led to a dose-dependent increase in plasma epinephrine concentration, systolic blood pressure, and heart rate, whereas diastolic blood pressure was decreased. PRA was elevated in a dose-dependent manner, whereas the plasma aldosterone concentration was reduced. During infusion of epinephrine, the serum potassium concentration and renal potassium excretion were significantly decreased. We conclude that despite marked stimulation of PRA, the plasma aldosterone concentration was further decreased because of a dose-dependent decrease in serum potassium concentration induced by epinephrine. Thus hypokalemia appears to be the predominant regulator of plasma aldosterone during incremental epinephrine infusion.

References

Sep 1, 1977·The Journal of Physiology·T Clausen, J A Flatman
May 1, 1979·The Journal of Endocrinology·J P CoghlanR D Wright
May 9, 1989·Biochimica Et Biophysica Acta·K J Sweadner
Aug 30, 1985·The American Journal of Cardiology·M J Brown
Jul 1, 1986·Kidney International·R S Brown
Feb 1, 1985·Kidney International·M J Field, G J Giebisch
May 1, 1985·Clinical and Experimental Pharmacology & Physiology·I F MusgraveR D Gordon
Mar 1, 1973·The Journal of Clinical Endocrinology and Metabolism·R W FarmerL F Fabre
Jul 1, 1981·Kidney International·R A DeFronzoG Birkhead

❮ Previous
Next ❯

Citations

Dec 29, 2004·Domestic Animal Endocrinology·S JavadiA Rijnberk
Jun 28, 2016·The Annals of Thoracic Surgery·Sivaprasad VeerbhadranJaganathan Raghavan
Feb 11, 2010·Journal of Diabetes Science and Technology·Toke Folke ChristensenOle Kristian Hejlesen
Apr 7, 2007·Shock·Alan L BealGreg J Beilman
Jul 16, 2015·American Journal of Physiology. Endocrinology and Metabolism·Yoskaly Lazo-FernandezSusan M Wall

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.