Role of ER-α36 in breast cancer by typical xenoestrogens

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Jun LiuXuejun Pan

Abstract

About 10 years have passed since the discovery of the estrogen receptor subtype, estrogen receptor alpha 36 (ER-α36). The relationship between cancerous cells and ER-α36 in mediating xenoestrogens (XEs) is a significant issue in the progression and treatment of breast cancer. XEs can combine with classical estrogen receptors and other receptor subtypes especially ER-α36, resulting in activation of nongenomic pathways as well as genomic pathways. Recently, most laboratories have focused on further study into the rapidly nongenomic mechanisms by overexpressing or knocking down ER-α36 in breast cancer cell lines. These rapid responses can induce the deregulation of cell cycle, and then lead to the abnormal proliferation and differentiation by regulating distinct downstream pathways. It appears that ER-α36 is a key factor in increasing risk of breast cancer. However, in several recent studies, the action mechanisms of ER-α36 by XEs in breast cancer cell lines are not always clear. In this review, we firstly summarize the expression pattern and tumor biology of ER-α36, then discuss these related estrogenic effects of ER-α36, and lastly give the predictive and prognostic value of ER-α36 as diagnostic marker by mediating typical XEs i...Continue Reading

References

Dec 24, 1987·Cell·V KumarP Chambon
Jun 12, 1995·Annals of the New York Academy of Sciences·R I NicholsonB S Katzenellenbogen
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·S M AronicaB S Katzenellenbogen
Nov 7, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T OkuboI Kano
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·E V JensenJ A Gustafsson
Nov 8, 2002·The Journal of Biological Chemistry·Mahnaz RazandiEllis R Levin
Feb 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Marcello MaggioliniSebastiano Amdò
Jun 7, 2003·Endocrine-related Cancer·S F Doisneau-SixouR L Sutherland
Jun 17, 2004·Molecular and Cellular Biology·Mahnaz RazandiEllis R Levin
Apr 9, 2005·The Journal of the British Menopause Society·Martin K OehlerThomas W Jobling
Sep 17, 2005·Biochemical and Biophysical Research Communications·Zhaoyi WangThomas F Deuel
Dec 3, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·H Y Ye, Y J Lou
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Zhaoyi WangThomas F Deuel
Sep 13, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Suman RiceSaffron A Whitehead
Jan 16, 2007·Molecular Carcinogenesis·Valeria C GrossoniAlejandro J Urtreger
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Gabriella CastoriaFerdinando Auricchio
Jan 8, 2008·Breast Cancer Research and Treatment·Andreas Stang, Christoph Thomssen
Jun 3, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Liang ShiYuntao Xie
Sep 28, 2010·Environmental Health Perspectives·Yow-Jiun Jeng, Cheryl S Watson
Sep 6, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Jun RaoBin Chen
Sep 13, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Lianguo KangZhao-Yi Wang
Mar 15, 2012·American Journal of Physiology. Endocrinology and Metabolism·Adelaide Del ViscovoLorella M T Canzoniero

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Citations

Jul 4, 2017·Expert Opinion on Therapeutic Targets·Luis MolinaPamela Ehrenfeld
Jan 28, 2020·International Journal of Molecular Medicine·Zhao-Heng LinXi-Yun Shan

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