Role of ERRF, a novel ER-related nuclear factor, in the growth control of ER-positive human breast cancer cells.

The American Journal of Pathology
Dan SuJin-Tang Dong

Abstract

Whereas estrogen-estrogen receptor α (ER) signaling plays an important role in breast cancer growth, it is also necessary for the differentiation of normal breast epithelial cells. How this functional conversion occurs, however, remains unknown. Based on a genome-wide sequencing study that identified mutations in several breast cancer genes, we examined some of the genes for mutations, expression levels, and functional effects on cell proliferation and tumorigenesis. We present the data for C1orf64 or ER-related factor (ERRF) from 31 cell lines and 367 primary breast cancer tumors. Whereas mutation of ERRF was infrequent (1 of 79 or 1.3%), its expression was up-regulated in breast cancer, and the up-regulation was more common in lower-stage tumors. In addition, increased ERRF expression was significantly associated with ER and/or progesterone receptor (PR) positivity, which was still valid in human epidermal growth factor receptor 2 (HER2)-negative tumors. In ER-positive tumors, ERRF expression was inversely correlated with HER2 status. Furthermore, higher ERRF protein expression was significantly associated with better disease-free survival and overall survival, particularly in ER- and/or PR-positive and HER2-negative tumors (...Continue Reading

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Citations

Apr 30, 2016·Biochemical and Biophysical Research Communications·Ang Luo, Xuan Zhang
Sep 8, 2016·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Ang LuoJin-Tang Dong
Apr 17, 2020·Cancer Biotherapy & Radiopharmaceuticals·Taobo JinTianya Zhang
Feb 25, 2018·Proceedings of the National Academy of Sciences of the United States of America·Konstantinos V FlorosAnthony C Faber

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