Role of Escherichia coli DNA polymerase IV in in vivo replication fidelity

Journal of Bacteriology
Wojciech KubanIwona J Fijalkowska

Abstract

We have investigated whether DNA polymerase IV (Pol IV; the dinB gene product) contributes to the error rate of chromosomal DNA replication in Escherichia coli. We compared mutation frequencies in mismatch repair-defective strains that were either dinB positive or dinB deficient, using a series of mutational markers, including lac targets in both orientations on the chromosome. Virtually no contribution of Pol IV to the chromosomal mutation rate was observed. On the other hand, a significant effect of dinB was observed for reversion of a lac allele when the lac gene resided on an F'(pro-lac) episome.

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Citations

Sep 19, 2006·Journal of Bacteriology·Wojciech KubanIwona J Fijalkowska
Feb 9, 2010·Journal of Bacteriology·Bavesh D KanaValerie Mizrahi
Dec 7, 2010·Journal of Bacteriology·Kimberly A M Storvik, Patricia L Foster
Oct 17, 2006·Journal of Bacteriology·Laurie H SandersMark D Sutton
Jan 9, 2007·Journal of Bacteriology·Jeffrey D StumpfPatricia L Foster
Jan 5, 2005·Journal of Bacteriology·Jill C Layton, Patricia L Foster
May 25, 2006·Annual Review of Microbiology·Takehiko Nohmi
Mar 25, 2014·Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis·Mei-Chong W LeeNeil J Sargentini
Dec 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Daniel F JaroszGraham C Walker
Oct 16, 2015·Proceedings of the National Academy of Sciences of the United States of America·Patricia L FosterHaixu Tang
May 12, 2011·Mutation Research·Marc BicharaIain B Lambert
Apr 5, 2011·Mutation Research·K Makiela-DzbenskaI J Fijalkowska
Jan 9, 2007·Trends in Microbiology·Daniel F JaroszGraham C Walker
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Jun 20, 2020·FEMS Microbiology Reviews·Asha Mary Joseph, Anjana Badrinarayanan
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