Role of estradiol in the dynamic control of tanycyte plasticity mediated by vascular endothelial cells in the median eminence.

Endocrinology
Sandrine de SerannoVincent Prevot

Abstract

In the ever-changing physiological context of the neuroendocrine brain, the mechanisms by which cellular events involving neurons, astroglia, and vascular cells are coordinated to bring forth the appropriate neuronal signaling is not yet known but is amenable to examination. In the median eminence of the hypothalamus, endothelial cells are key players in the plasticity of tanycytes (specialized astroglia) and neuroendocrine synapse efficacy. Here we report that estradiol acts on both purified endothelial cells and isolated tanycytes to trigger endothelial-to-glial communication that leads to a sudden and massive retraction of tanycyte processes. The blockade of endothelial nitric oxide synthase by in vitro adenoviral-mediated gene transfer of a dominant-negative form of endothelial nitric oxide synthase abrogates the estradiol-induced tanycyte plasticity mediated by endothelial cells. In parallel, increases in prostaglandin-E(2) (PGE(2)) due to changes in cyclooxygenase (COX)-1 and COX-2 expression induced by the exposure of tanycytes to estradiol promote acute tanycyte plasticity. We also demonstrate by electron microscopy that the administration of PGE(2) to median eminence explants induces rapid neuroglial plasticity at the ...Continue Reading

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Citations

Oct 11, 2011·Biologie aujourd'hui·Clémence Girardet, Olivier Bosler
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Jan 31, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sarah Berga, Frederick Naftolin
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Jun 16, 2010·Frontiers in Neuroendocrinology·Vincent PrevotMarc Baroncini
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Jul 28, 2019·British Journal of Pharmacology·Konstantina Chachlaki, Vincent Prevot
Apr 14, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K Max ColdrenCheryl M Heesch
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Aug 30, 2020·Molecular and Cellular Endocrinology·Kathryn B Smedlund, Jennifer W Hill
Jan 28, 2020·Neuroendocrinology·Fanny Langlet

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