Role of estrogen in nitric oxide- and prostaglandin-dependent modulation of vascular conductance during treadmill locomotion in rats

Journal of Applied Physiology
Jennifer Rogers, Don D Sheriff

Abstract

Endothelial production of nitric oxide (NO) and prostaglandins (PG) may be greater in females than in males, increasing vasodilatory responses in females. Does sex influence the cardiovascular responses to dynamic exercise through estrogen-dependent modulation of NO and PG vasodilatory pathways? After the administration of hexamethonium, we assessed terminal aortic blood flow (TAQ), mean arterial pressure (MAP), and hindlimb vascular conductance (VC) in four groups of rats (6 males, 5 females, 5 ovariectomized females, and 6 ovariectomized females with chronic estrogen supplementation) during graded mild-intensity treadmill locomotion (5-15 m/min, 0 degrees grade, 2 min). All rats repeated exercise after cyclooxygenase inhibition (indomethacin) and then again after NO synthase inhibition (nitro-l-arginine methyl ester) to examine the roles of NO and PG. Regression analysis was used to determine the influence of sex and plasma 17beta-estradiol on TAQ, MAP, and VC. The analysis revealed that female sex did not influence TAQ but reduced MAP and increased VC at rest and during exercise conditions. Plasma 17beta-estradiol (measured by immunoassay) significantly decreased MAP and increased TAQ and VC, irrespective of sex. Cyclooxygen...Continue Reading

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Citations

Jul 16, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Steven K NishiyamaRussell S Richardson
Sep 23, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Zheng F Ba, Irshad H Chaudry
Aug 21, 2010·Journal of Applied Physiology·Jacqueline K LimbergWilliam G Schrage
Jul 5, 2011·Microvascular Research·Koji TominagaYasufumi Kataoka
Jan 27, 2015·Clinical Physiology and Functional Imaging·Aki OtsukiMayumi Kuno-Mizumura
Sep 3, 2013·Respiratory Physiology & Neurobiology·Juan M MuriasDonald H Paterson
Mar 31, 2015·European Journal of Applied Physiology·J Mikhail KellawanWilliam G Schrage
Jan 28, 2017·Journal of Applied Physiology·Joshua R SmithTimothy I Musch
Jan 26, 2018·Journal of Applied Physiology·Jesse C CraigDavid C Poole
Jan 19, 2008·Medicine and Science in Sports and Exercise·Koichiro HayashiMitsuo Matsuda
Mar 5, 2018·European Journal of Applied Physiology·Heather ReillyMikel Egaña
Jan 11, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Zheng F BaIrshad H Chaudry
Aug 25, 2007·Journal of Applied Physiology·Beth A ParkerDavid N Proctor
Jul 5, 2013·Journal of Applied Physiology·Darren P CaseyMichael J Joyner
Oct 13, 2007·Journal of Applied Physiology·Joaquin U GonzalesBarry W Scheuermann
Aug 2, 2007·Molecular and Cellular Biochemistry·Amélie PaquetteJean-Marc Lavoie

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