PMID: 1194459Aug 1, 1975Paper

Role of estrogens in androgen-induced spontaneous activity in male rats

Journal of Comparative and Physiological Psychology
E J Roy, G N Wade

Abstract

Three experiments tested the hypothesis that testosterone may be aromatized to an estrogen to stimulate running-wheel activity in rats. Aromatizable (testosterone propionate: TP) and nonaromatizable (dihydrotestosterone propionate; DHTP) androgens were compared with estradiol benzoate (EB) for the ability to induce running in castrated male rats. The DHTP had no effect on running. The TP increased running, but EB was more than 100 times as effective. A relatively small dose of a specific estrogen antagonist, MER-25, was shown to attenuate the effects of both EB and TP on male running. The MER-25 did not affect the running of castrated, oil-treated male rats and did not inhibit the running induced by food deprivation.

Citations

May 1, 1978·Physiology & Behavior·S A Browne, K T Borer
Mar 1, 1979·Physiology & Behavior·G N Wade, J M Gray
Feb 1, 1980·Physiology & Behavior·D L RowlandJ A Thommes
Mar 1, 1980·Physiology & Behavior·A A NunezG N Wade
Apr 1, 1983·Pharmacology, Biochemistry, and Behavior·J W KemnitzG A Bray
Dec 4, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Tomoaki SatoTakashige Nishikawa
Apr 7, 2007·Menopause : the Journal of the North American Menopause Society·Dominik RachońWolfgang Wuttke
May 2, 2008·International Journal of Biological Sciences·J Timothy Lightfoot
Aug 17, 2011·Journal of Nutrition and Metabolism·Jean-Marc Lavoie, Abdolnaser Pighon
Oct 30, 2009·Climacteric : the Journal of the International Menopause Society·H J TeedeA A Deeks
Oct 13, 2009·Molecular and Cellular Endocrinology·Dominik Rachoń, Helena Teede
Mar 1, 1983·Hormones and Behavior·J Broida, B Svare
Jan 1, 1985·Annals of the New York Academy of Sciences·K C Chambers
Jan 1, 1986·Annals of the New York Academy of Sciences·G N Wade
Mar 29, 2006·Biological Psychiatry·Rachel A HillWah Chin Boon
Feb 25, 2006·Hormones and Behavior·Lance J Kriegsfeld, Rae Silver
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·G N Wade, J E Schneider
Jun 9, 2016·The Veterinary Clinics of North America. Small Animal Practice·Robert Backus, Allison Wara
Feb 6, 2003·Journal of Biological Rhythms·Tammy J JechuraTheresa M Lee
Jul 14, 2017·Exercise and Sport Sciences Reviews·Michael D RobertsFrank W Booth
Nov 23, 2017·Medicine and Science in Sports and Exercise·J Timothy LightfootClaude Bouchard
Mar 15, 2018·Medicine and Science in Sports and Exercise·Nicole L StottRobert S Bowen
Jan 19, 2018·Scientific Reports·Ferran JardíDirk Vanderschueren
Oct 3, 2018·The European Journal of Neuroscience·Katherine M HatcherMegan M Mahoney
May 11, 2018·The Journal of Endocrinology·Ferran JardíFrank Claessens

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