Role of etravirine in combination antiretroviral therapy

Enfermedades infecciosas y microbiología clínica
Pere Domingo

Abstract

Etravirine (ETR) is a new antiretroviral drug of the non-nucleoside reverse transcriptase inhibitor (NNRTI) family that has recently been approved by the regulatory agencies for the treatment of patients with prior experience with antiretrovirals, evidence of active viral replication, and who harbor multidrug resistant HIV-1 strains. In this context, in Europe, the use of this drug has been authorized combined with boosted protease inhibitors and nucleoside reverse transcriptase inhibitors. This approval was based on the results of the randomized double-blind DUET studies, in which the ETR arm was statistically superior to the placebo arms in terms of virological efficacy, immunological recovery, clinical progression and health- related quality of life. These studies showed that ETR was as well-tolerated as placebo, except for the appearance of rash, which was more common in the ETR arm. However, rash was usually mild or moderate and caused discontinuation of ETR in only 2% of the patients. The characteristics of ETR, i.e., potency, benign safety profile, resistance profile, pharmacokinetic characteristics, and drug interactions suggest that the use of this drug may go beyond its currently approved indications. Nevertheless, th...Continue Reading

References

Jun 4, 2008·AIDS·Rebecca K LodwickAndrew N Phillips
Jul 17, 2008·Current HIV/AIDS Reports·Kavita P BhavanEdgar Turner Overton
Jul 25, 2008·The New England Journal of Medicine·Roy T SteigbigelUNKNOWN BENCHMRK Study Teams
Aug 5, 2008·JAMA : the Journal of the American Medical Association·Scott M HammerUNKNOWN International AIDS Society-USA
Oct 10, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Y YazdanpanahUNKNOWN ANRS 139 TRIO Trial Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Enfermedades infecciosas y microbiología clínica
Daniel Podzamczer PalterJuan Manuel Tiraboschi
Enfermedades infecciosas y microbiología clínica
Piedad Arazo Garcés, Esther Valero Tena
Enfermedades infecciosas y microbiología clínica
Joaquín Portilla
© 2021 Meta ULC. All rights reserved