PMID: 8945957Nov 1, 1996Paper

Role of excitatory amino acid receptors in cardiorespiratory coupling in ventrolateral medulla

The American Journal of Physiology
T MiyawakiPaul M Pilowsky

Abstract

The role of (+/-)-alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA)-kainate and N-methyl-D-aspartate (NMDA) receptors in the rostral ventrolateral medulla (RVLM) and caudal ventrolateral medulla (CVLM) on the central respiratory drive (CRD)-related activity of splanchnic sympathetic nerve activity (SNA) was examined in rats. SNA increased during inspiration (I peak) and postinspiration (PI peak). Bilateral microinjections of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; AMPA-kainate antagonist) or DL-2-amino-5-phosphonovaleric acid (APV; NMDA antagonist) into RVLM abolished the PI, but not the I, peak. Blockade of all excitatory amino acid receptors in RVLM with kynurenate, or mixtures of APV and CNQX, also failed to eliminate the I peak. Somatosympathetic responses were abolished by CNQX injection into RVLM, but were unaffected by APV. CNQX, but not APV, injection into CVLM increased the PI peak of SNA. Our findings suggest the following. 1) Both NMDA and AMPA-kainate receptors in RVLM are involved in the coupling between the sympathetic nervous system and CRD, which generates the PI peak seen in SNA. 2) The I peak of SNA is independent of excitatory amino acid transmission within RVLM. 3) There are different rela...Continue Reading

Citations

Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Y F LiK P Patel
Feb 26, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John M MakehamPaul M Pilowsky
Jan 23, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stephen B G Abbott, Paul M Pilowsky
Apr 22, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Min-Seok Kim, Jae-Joong Kim
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T MiyawakiP M Pilowsky
Mar 11, 2006·The Journal of Physiology·Daniel A Mandel, Ann M Schreihofer
Aug 1, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Yi-Fan LiKaushik P Patel
Dec 3, 2008·The Journal of Physiology·Daniel A Mandel, Ann M Schreihofer
Jan 21, 2012·The Journal of Pharmacology and Experimental Therapeutics·Ahmed A RahmanPaul M Pilowsky
Sep 21, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T Luise KingEileen M Hasser

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