Role of excretory graft function for erythropoietin formation after renal transplantation

European Journal of Clinical Investigation
K U EckhardtA Kurtz

Abstract

To examine the role of renal excretory function for erythropoietin (EPO) formation we have determined the kinetics of plasma immunoreactive EPO (irEPO) in patients with end-stage renal disease undergoing renal allotransplantation (RTX). In 13 patients with immediate excretory graft function (imGF) and stable haemoglobin (Hb) concentrations (median Hb 9.5 g dl-1 and median irEPO 18 mU ml-1 before RTX) irEPO increased significantly on day 4 after RTX to a median value of 29 mU ml-1 and 2 days later reached a plateau of 34.4 +/- 3.3 mU ml-1 (mean +/- SD of daily median values during days 6-20). In patients with imGF having acute blood loss and subsequently receiving transfusions, irEPO responded in an inverse fashion to changes in Hb concentrations. In 12 patients with delayed graft function (dGF) (median Hb 8.8 g dl-1 and median irEPO 15 mU ml-1 before RTX) irEPO levels during the period of excretory failure remained either unchanged or displayed marked variations with peak values greatly exceeding those of patients with imGF. These variations were not related to changes in Hb concentrations and irEPO levels did not change following alterations in Hb concentrations. Upon recovery of excretory function irEPO approached the values ...Continue Reading

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Citations

Mar 1, 1994·Annals of Hematology·A LorentzC Kruse
Sep 1, 1995·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·R PereraH Kaufmann
Dec 1, 2010·Journal of the American Society of Nephrology : JASN·Wanja M BernhardtKai-Uwe Eckardt
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Peter D YorginSteven R Alexander
Mar 22, 2007·Kidney & Blood Pressure Research·Josef ZadrazilMiroslav Hrubý

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