Role of exogenous melatonin in reducing the cardiotoxic effect of daunorubicin and doxorubicin in the rat

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Piotr DzięgielMaciej Zabel

Abstract

The aim of the studies was to examine the cardioprotective effect of melatonin during the anthracycline administration (daunorubicin, doxorubicin) in rats. Application of these drugs in chemotherapy is limited because of their cardiotoxicity. Rats of Buffalo strain were divided into groups according to the cytostatic drug used, its dose and sequence of administration (single intravenous [i.v.] dose of 10 mg/kg b.w., i.e., acute intoxication; 3 mg/kg b.w. weekly for 3 weeks, subchronic intoxication). Melatonin was administered subcutaneously before and after every injection of a cytostatic drug at a dose of 10 mg/kg b.w. The degree of cardiac muscle cell alterations was examined either histologically (Mean Total Score technique and the Billingham scale), or biochemically (levels of lipid peroxidation markers, malonyldialdehyde, and 4-hydroxyalkenals). Statistically significant decrease in cardiac muscle cell damage was noted with an aid of the Billingham scale after melatonin administration in acutely intoxicated doxorubicin-treated rats (p < 0.001). The similar phenomenon was observed using the Mean Total Score technique in case of acute daunorubicin or doxorubicin (p < 0.01 and p < 0.001, respectively) intoxications. A signifi...Continue Reading

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Citations

Dec 1, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Eugenia Murawska-CiałowiczPiotr Dzięgiel
Nov 9, 2010·The Journal of Pharmacy and Pharmacology·Wawaimuli ArozalYoshifusa Aizawa
Sep 17, 2020·Human & Experimental Toxicology·S ZareG Karimi
Apr 14, 2006·Molecular and Cellular Biochemistry·Yilmaz CigremisAhmet Acet
Aug 10, 2017·International Journal of Molecular Sciences·Magdalena FicKarolina Jablonska

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