PMID: 9541225Apr 16, 1998Paper

Role of exogenous TGF-beta in induction of reparative dentinogenesis in vivo

European Journal of Oral Sciences
D Tziafas, S Papadimitriou

Abstract

This study was designed to investigate in vivo i) the role of TGF-beta as an active component of the dentin matrix during induction of reparative dentinogenesis; and ii) the ability of TGF-beta1 isoform to induce dentinogenic events. Dental pulps of dog molars and canines were mechanically exposed, and the following implants were placed intrapulpally for 42 d: i) Demineralized or native autogenous dentin matrix preincubated with a TGF-beta-neutralizing antibody; ii) Millipore filters soaked with solution containing 100 ng/ml of TGF-beta1 from human platelets; iii) biomatrices and filters soaked in control solutions. After incubation of biomatrices with the TGF-beta-neutralizing antibody, demineralized dentin completely lost its inductive activity, while native dentin was only able to stimulate formation of fibrodentin. Millipore filters soaked with TGF-beta1 were consistently surrounded by a thick zone of tubular matrix lined with high columnar polarized cells. The data provide evidence that pulp cells can express their dentinogenic potential in response to an appropriate surface containing exogenous TGF-beta1, and that the dentinogenic activity of dentin matrix may at least partly be ascribed to TGF-beta molecule(s).

Citations

Dec 18, 2013·Dental Materials : Official Publication of the Academy of Dental Materials·Fang LiHockin H K Xu
Jun 29, 2010·Journal of Dentistry·Paul R CooperAnthony J Smith
Feb 13, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Cristiane FuruseVera Cavalcanti de Araújo
Jul 28, 2012·Dental Clinics of North America·Sahng G KimJeremy J Mao
Oct 18, 2001·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·G EmberyM Goldberg
Jun 12, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Tamizchelvi ThyagarajanAshok B Kulkarni
Mar 31, 2015·Journal of Dental Research·Y H AhnE S Cho
Dec 21, 2016·Journal of Biomedical Materials Research. Part a·Wellington Luiz de Oliveira da RosaAdriana Fernandes da Silva
Dec 4, 2016·Dental Clinics of North America·Sahng G Kim
May 2, 2009·Journal of Dental Research·O V HorstB A Dale
Mar 19, 2003·Advances in Dental Research·P K DenBestenE Filvaroff
Nov 27, 2015·Dentistry Journal·Dimitrios Tziafas, Konstantinos Kodonas
Jul 15, 2017·The International Journal of Artificial Organs·Merve Kurun AksoyKaan Orhan
Sep 21, 2010·Journal of Endodontics·Fu-Mei HuangYu-Chao Chang
Dec 31, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Kyeong-Rok KangDo Kyung Kim

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