PMID: 20650070Apr 1, 1995Paper

Role of extracellular calcium and calcium stores in the intracellular calcium rise induced by diethylstilboestrol in C6 rat glioma cells

Toxicology in Vitro : an International Journal Published in Association with BIBRA
P TasD Schiffmann

Abstract

The aneuploidy-inducing carcinogenic oestrogen diethylstilboestrol (DES) causes an elevation of the cytoplasmic Ca(2+) concentration of C6 rat glioma cells. It is known that the intracellular calcium concentration is a critical factor in mitosis. DES induces mitotic disturbances resulting in aneuploidy; the mechanisms of these events are still largely unknown. It is therefore important to identify the calcium source for the DES-mediated calcium rise. Experiments with isolated rat liver mitochondria showed no release of calcium after DES treatment. However, DES releases calcium from the same stores as the tumour promotor thapsigargin, which are the inositol 1,4,5-triphosphate- and GTP-sensitive Ca(2+) stores. In contrast to DES, thapsigargin also induces a calcium influx into the cell. Administration of DES following thapsigargin treatment strongly reduced the thapsigargin-mediated calcium entry. Furthermore, DES inhibits the decay of the ionomycin-induced calcium signal, suggesting an interference of DES with the extrusion of calcium from the cell. In conclusion, thapsigargin and DES both cause release of calcium from the endoplasmic reticulum. However, for each compound the prolongation of the calcium signal is based on differ...Continue Reading

References

Nov 11, 1990·Cell Calcium·J W Putney
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·O ThastrupA P Dawson
Oct 1, 1990·Journal of Neurochemistry·S H ChuehL S Kao
Sep 21, 1989·Nature·M J Berridge, R F Irvine
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J M MullaneyD L Gill
Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P TasD Schiffmann

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