Role of Extracellular Vesicles in Amyotrophic Lateral Sclerosis

Frontiers in Neuroscience
Deborah FerraraManuela Basso

Abstract

Amyotrophic Lateral Sclerosis (ALS) is the most common motor neuron disease in adults and primarily targets upper and lower motor neurons. The progression of the disease is mostly mediated by altered intercellular communication in the spinal cord between neurons and glial cells. One of the possible ways by which intercellular communication occurs is through extracellular vesicles (EVs) that are responsible for the horizontal transfer of proteins and RNAs to recipient cells. EVs are nanoparticles released by the plasma membrane and this review will describe all evidence connecting ALS, intercellular miscommunication and EVs. We mainly focus on mutant proteins causing ALS and their accumulation in EVs, along with the propensity of mutant proteins to misfold and propagate through EVs in prion-like behavior. EVs are a promising source of biomarkers and the state of the art in ALS will be discussed along with the gaps and challenges still present in this blooming field of investigation.

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Citations

Jun 26, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Caterina BendottiEttore Beghi
Aug 28, 2019·International Journal of Molecular Sciences·Paola RivaMarco Venturin
May 24, 2019·Journal of Translational Medicine·William R SwindellJohn J Kopchick
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Aug 12, 2021·Molecular Neurodegeneration·Laura PasettoValentina Bonetto
Oct 2, 2021·Molecular Neurobiology·Sharanjot KaurAnil K Mantha

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Methods Mentioned

BETA
transgenic
RNA-seq
medical procedure

Software Mentioned

ExoCarta

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Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

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