Role of extrinsic and intrinsic nerves in hormonal induction of the migrating motor complex in the jejunum

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
N S HakimM G Sarr

Abstract

The mechanism of induction of the migrating motor complex (MMC) by neural or humoral agents and their role in the control of fasting motility are not well understood. Our aim was to determine the role of extrinsic and intrinsic nerves in mediating the induction of the MMC by motilin. Three groups of dogs were studied. Group I consisted of neurally intact control dogs. In group II, intrinsic neural continuity between the duodenum and the jejunum was interrupted by transection and reanastomosis of the distal duodenum. Dogs in group III underwent disruption of all intrinsic and extrinsic neural input to the entire jejunoileum. Serosal electrodes were sewn to duodenum and jejunum in all dogs. After a 2-week recovery, fasting myoelectric activity was recorded on four or more occasions. Motilin (0.1 microgram/kg iv) was given 30 min after a spontaneous duodenal phase III. In group I (controls), motilin induced a premature MMC, which originated in the duodenum and migrated along the small intestine. In group II (intrinsic neural disruption), motilin induced a premature MMC, which began simultaneously in the proximal duodenum and proximal jejunum. In group III (intrinsic and extrinsic neural disruption), motilin induced a premature MMC...Continue Reading

References

Jul 1, 1979·Digestive Diseases and Sciences·G VantrappenJ Hellemans
Aug 1, 1979·Digestive Diseases and Sciences·P A ThomasV L Go
Oct 1, 1978·The American Journal of Digestive Diseases·Z ItohN Yanaihara
Mar 1, 1975·The Journal of Physiology·C F Code, J A Marlett
Mar 1, 1988·Gastroenterology·M Tanaka, M G Sarr
Apr 1, 1986·Digestive Diseases and Sciences·L MarzioG A Lanfranchi
Mar 1, 1985·The American Journal of Physiology·P Hellstrand, H J Vogel
Jan 1, 1974·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·A G PearseJ C Brown
Dec 1, 1969·The American Journal of Physiology·J H Szurszewski
Mar 5, 1984·Life Sciences·J E FoxH Robotham

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