Role of Extrinsic Apoptotic Signaling Pathway during Definitive Erythropoiesis in Normal Patients and in Patients with β-Thalassemia.

International Journal of Molecular Sciences
Olga Raducka-JaszulAleksander F Sikorski


Apoptosis is a process of programmed cell death which has an important role in tissue homeostasis and in the control of organism development. Here, we focus on information concerning the role of the extrinsic apoptotic pathway in the control of human erythropoiesis. We discuss the role of tumor necrosis factor α (TNFα), tumor necrosis factor ligand superfamily member 6 (FasL), tumor necrosis factor-related apoptosis-inducing (TRAIL) and caspases in normal erythroid maturation. We also attempt to initiate a discussion on the observations that mature erythrocytes contain most components of the receptor-dependent apoptotic pathway. Finally, we point to the role of the extrinsic apoptotic pathway in ineffective erythropoiesis of different types of β-thalassemia.


Aug 1, 1990·The Journal of Clinical Investigation·R T MeansSanford B Krantz
Jan 1, 1970·Medicine·C A FinchE R Biblett
Feb 1, 1993·The Journal of Clinical Investigation·R T Means, Sanford B Krantz
Jun 1, 1996·The Journal of Cell Biology·M WeilM C Raff
Feb 27, 1999·Journal of Cellular Physiology·P A Gregoli, M C Bondurant
Feb 24, 2001·The Journal of Experimental Medicine·Yael ZermatiOlivier Hermine
Oct 24, 2001·Journal of Hematotherapy & Stem Cell Research·A OdaK Sawada
Feb 14, 2002·Trends in Biochemical Sciences·Jean-Luc BodmerJürg Tschopp
Feb 15, 2002·Current Opinion in Hematology·Stanley L Schrier
Nov 9, 2002·Experimental Hematology·Weiguo XiaoKen ichi Sawada
Dec 19, 1959·Nature·V M INGRAM, A O STRETTON
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·Svetlana MyssinaFlorian Lang
Feb 14, 2004·Redox Report : Communications in Free Radical Research·Stanley L SchrierEmanuele Angelucci
Feb 21, 2004·Blood·Graeme W CarlileMartin Wiedmann
Feb 19, 2005·Science·Joseph T OpfermanStanley J Korsmeyer
Mar 5, 2005·Cell Death and Differentiation·P A LangS M Huber
Mar 18, 2005·The Journal of Biological Chemistry·Delphine MilhasBruno Ségui
Apr 15, 2005·Human Molecular Genetics·Ming-De YanShuang-En Chuang
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nadia FelliRuggero De Maria
Sep 17, 2005·Blood·Prisco MirandolaMarco Vitale
Dec 13, 2005·The Journal of Biological Chemistry·Brendan P Eckelman, Guy S Salvesen
Sep 29, 2006·The EMBO Journal·Takayoshi KirisakoKazuhiro Iwai
Dec 15, 2006·Nature·Jean-Antoine RibeilOlivier Hermine
Dec 27, 2006·Free Radical Biology & Medicine·Donatella PietraforteMaurizio Minetti
Sep 15, 2007·Biochemical and Biophysical Research Communications·Yuichi MikiMasatoshi Beppu
Apr 2, 2008·Toxicology and Applied Pharmacology·Debabrata BiswasTuli Biswas
Jun 24, 2008·Bulletin of the World Health Organization·Bernadette Modell, Matthew Darlison
Jul 25, 2008·Blood·Joel Anne Chasis, Narla Mohandas
Oct 17, 2008·Experimental Hematology·Steve ElliottIain C Macdougall
Dec 23, 2008·Experimental Hematology·Randolph M AbutinHisashi Harada
Jan 15, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria Eugenia Guicciardi, Gregory J Gores
Feb 27, 2009·FEBS Letters·Graeme W CarlileMartin Wiedmann
Jun 26, 2010·Trends in Immunology·Léa Tourneur, Gilles Chiocchia
Jul 24, 2010·Nature Reviews. Cancer·Mads Gyrd-Hansen, Pascal Meier
Aug 5, 2010·International Journal of Laboratory Hematology·D SaganOrathai Tangvarasittichai
Nov 13, 2010·Cell Death and Differentiation·Z T SchugE Gottlieb
Nov 16, 2010·Hematology/oncology Clinics of North America·David J WeatherallA O'Donnell
Feb 5, 2011·Experimental Hematology·Scott A PeslakJames Palis
Apr 2, 2011·Nature·Björn GerlachHenning Walczak
Jun 28, 2011·Journal of Translational Medicine·Saranyoo PonnikornSumalee Tungpradabkul
Aug 31, 2011·Cellular and Molecular Life Sciences : CMLS·Beata MachnickaM C Lecomte
Jan 25, 2012·Blood Purification·Florian Lang, Syed M Qadri
Mar 21, 2012·British Journal of Haematology·Mehrdad GhashghaeiniaGiel J C G M Bosman
Aug 22, 2012·Cold Spring Harbor Perspectives in Medicine·Suthat Fucharoen, David J Weatherall
Nov 6, 2012·Cellular & Molecular Biology Letters·Marcin A ListowskiAleksander F Sikorski
Jan 26, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kylie D MasonLorraine A O'Reilly
Feb 5, 2013·Cold Spring Harbor Perspectives in Biology·John Silke, Pascal Meier
Mar 5, 2013·Cold Spring Harbor Perspectives in Medicine·H Franklin Bunn
Apr 3, 2013·Cold Spring Harbor Perspectives in Medicine·Elaine Dzierzak, Sjaak Philipsen
May 7, 2013·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·Olivier HermineGeneviève Courtois
May 16, 2013·Biochimica Et Biophysica Acta·Beata MachnickaAleksander F Sikorski
Jun 5, 2013·Haematologica·Khaled M MusallamEliezer A Rachmilewitz
Jul 28, 2013·Advances in Immunology·Jixi LiHao Wu
Aug 27, 2013·Apoptosis : an International Journal on Programmed Cell Death·Felix M WensveenEric Eldering
Jan 31, 2014·Frontiers in Physiology·James Palis
Jan 1, 2013·Cells·Jean Berthelet, Laurence Dubrez
Mar 31, 2015·BioMed Research International·Elisabeth Lang, Florian Lang
Aug 22, 2015·Cell Death and Differentiation·Harald Wajant
May 8, 2014·Turkish Journal of Haematology : Official Journal of Turkish Society of Haematology·Dalina I TanyongSuthat Fucharoen
Feb 6, 2016·British Journal of Haematology·Satish K NandakumarVijay G Sankaran
Jul 28, 2016·Cell Reports·Emilie-Fleur GautierPatrick Mayeux
Sep 28, 2016·Molecular and Cellular Biology·Donghyun JooXin Lin
Nov 5, 2016·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Raffaella Origa
Nov 17, 2016·Acta biochimica Polonica·Klaudia Kulczyńska, Mirosława Siatecka
Nov 20, 2016·The FEBS Journal·Daniela SiegmundHarald Wajant
Oct 21, 2017·Cell Death and Differentiation·Halime Kalkavan, Douglas R Green
Nov 18, 2017·Cell Death and Differentiation·Justin KaleDavid W Andrews
Dec 3, 2017·Trends in Biochemical Sciences·Elodie LafontHenning Walczak
Mar 9, 2018·BioMed Research International·Lisa Repsold, Anna Margaretha Joubert
Jun 23, 2019·Experimental Biology and Medicine·Beata MachnickaAleksander F Sikorski
Oct 28, 2019·Cellular and Molecular Life Sciences : CMLS·Ayelén D NigraVerónica S Santander
Jan 1, 2018·Cell Death and Differentiation·Justin KaleDavid W Andrews
Jan 1, 2018·Cell Death and Differentiation·Halime Kalkavan, Douglas R Green


Oct 2, 2020·Antioxidants·Julia SudnitsynaIgor Mindukshev
May 1, 2021·International Journal of Molecular Sciences·Zhongjie YuBin Wang

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