Role of eye muscle antibody measurement in diagnosis of thyroid-associated ophthalmopathy: a laboratory update.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
S KubotaJ R Wall

Abstract

To review the current role of measurement of serum eye muscle antibodies in thyroid-associated ophthalmopathy (TAO). We conducted laboratory studies to determine the prevalences of serum autoantibodies reactive with eye muscle antigens in patients with active and inactive TAO, Graves' hyperthyroidism, and Hashimoto's thyroiditis as well as in normal subjects. The two antigens most often recognized in immunoblotting with crude human or porcine eye muscle membranes by serum autoantibodies in patients with TAO are eye muscle membrane proteins of 55 and 64 kd. One 64-kd eye muscle protein has recently been cloned by screening a human eye muscle expression library with two different antibody probes and identified from a computer gene bank search as the calcium-binding protein calsequestrin. A fragment of a 220-kd eye muscle protein, called G2s, has also been cloned by screening the eye muscle library with affinity-purified antibodies reactive with a 55-kd eye muscle membrane protein. The prevalences of autoantibodies reactive with these two antigens in our study groups were as follows. Antibodies against calsequestrin were detected in 38% of patients with TAO for <1 year, in 17% of those with TAO for >3 years, in 17% of patients wit...Continue Reading

References

Jan 1, 1992·Thyroid : Official Journal of the American Thyroid Association
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Jan 1, 1991·Thyroid : Official Journal of the American Thyroid Association·M SalviJ R Wall
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Jan 1, 1993·Developments in Ophthalmology·R S Bahn, A E Heufelder

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Citations

Aug 29, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kai-Chun ChengCheng-Hsien Chang
Feb 24, 2001·Critical Reviews in Clinical Laboratory Sciences·M YamadaJ R Wall
May 1, 2007·Expert Review of Clinical Immunology·Junichi TaniJack R Wall
May 29, 2004·Journal of Endocrinological Investigation·T MizokamiJ R Wall
May 29, 2004·Journal of Endocrinological Investigation·L BartalenaA Pinchera
Dec 9, 2020·Experimental & Molecular Medicine·Jin Seok WooEun Hui Lee

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