Role of F-18 FDG PET/CT in the follow-up of asymptomatic renal cell carcinoma patients for postoperative surveillance: based on conditional survival analysis.

Journal of Cancer Research and Clinical Oncology
Sohyun ParkSangchul Lee

Abstract

This study investigated the clinical usefulness of F-18 fluorodeoxylucose (FDG) positron emission tomography/computed tomography (PET/CT) for postoperative surveillance in the RCC patients in terms of detectability of recurrence and radiation exposure. Three-hundred-and-forty- three RCC patients who underwent surgery and postoperative surveillance were retrospectively included. Conditional recurrent free survival (CRFS) was investigated and diagnostic performance of conventional imaging (CI) which include abdominopelvic CT or/and chest CT was compared to the FDG PET/CT. At a median follow-up of 4.3 years (0.5-13.0 years), thirty-nine patients (11.4%) developed recurrence. CRFS of the patients increased over time with greater increment in advanced stage. The sensitivity, specificity, positive-predictive value, negative-predictive value, and accuracy of FDG PET/CT were 92.3%, 97%, 80%, 99.0%, and 96.5% in detecting recurrence, while those values for CI were 89.7%, 97.7%, 83.3%, 98.7%, and 96.8%, respectively. There were no significant differences in these values between FDG PET/CT and CI (McNemar test, p = 0.581). The average radiation dose from FDG PET/CT was around 16.9 ± 3.08 mSv at each follow-up time point. For early stage p...Continue Reading

References

Dec 19, 2003·The Urologic Clinics of North America·Nicolette K JanzenArie S Belldegrun
Mar 27, 2004·Radiology·Eric M RohrenR Edward Coleman
Dec 18, 2009·European Journal of Radiology·Koya NakataniKaori Togashi
Dec 22, 2009·Revista española de medicina nuclear·S Rodríguez Martínez de LlanoJ L Carreras-Delgado
Jul 28, 2010·Nuclear Medicine Communications·Rakesh KumarArun Malhotra
Oct 27, 2010·Journal of the National Cancer Institute·Igor ShuryakDavid J Brenner
Mar 8, 2012·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Mas JewettJ Willacy
Jul 24, 2012·Radiology·William R Hendee, Michael K O'Connor
Oct 31, 2012·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Hsin-Yi WangChia-Hung Kao
May 15, 2013·The Journal of Urology·Sherri M DonatSam S Chang
Feb 26, 2014·Clinical Nuclear Medicine·Chiara FuccioGiuseppe Trifirò
Jan 27, 2015·European Urology·Borje LjungbergAxel Bex
Feb 19, 2015·Journal of the National Comprehensive Cancer Network : JNCCN·Robert J MotzerUNKNOWN National comprehensive cancer network
Jul 15, 2015·Clinical Nuclear Medicine·Miwako TakahashiToshimitsu Momose
Dec 1, 2015·BJU International·Timothy J WilliamsonNathan Lawrentschuk
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 26, 2016·Journal of Korean Medical Science·Jinhee JangSung Su Hwang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.