PMID: 8967471May 1, 1996Paper

Role of fat-derived substrates in the regulation of gluconeogenesis during fasting

The American Journal of Physiology
F FeryE O Balasse

Abstract

To determine the role of fat-derived substrates in the regulation of glucose metabolism during fasting, glucose turnover, urea nitrogen production, alanine conversion to glucose, and substrate oxidation rates were measured in 34 normal 4-day-fasted volunteers treated with the antilipolytic drug acipimox or placebo for 8 h. The approximately 50% inhibition of lipolysis induced by acipimox increased glucose concentration and production, respectively, by approximately 35 and approximately 30%, whereas the protein breakdown and the amount of alanine converted to glucose were increased, respectively, by approximately 70 and approximately 85%. Insulin levels were reduced by approximately 40%, cortisol levels doubled, and growth hormone concentration increased sevenfold. The relative contribution of free fatty acid (FFA) and ketone body lowering to the observed response was evaluated in nine acipimox-treated subjects in whom ketone body concentration was clamped with an intravenous beta-hydroxybutyrate infusion. The results of these experiments suggest that, during fasting, both FFA and ketone bodies tend to suppress gluconceogenesis and to protect the protein stores. FFA seem to exert their effects mainly through their ability to mod...Continue Reading

Citations

Feb 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R M OrtizC L Ortiz
Jan 31, 2008·Journal of Clinical Biochemistry and Nutrition·Keiichi KojimaMichio Kasai
Jul 14, 2000·American Journal of Physiology. Endocrinology and Metabolism·W WangM K Hellerstein
Aug 29, 2019·Proceedings. Biological Sciences·Derrick J E GroomAlexander R Gerson
May 29, 2004·American Journal of Physiology. Endocrinology and Metabolism·Huynh van ThienH P Sauerwein
Oct 18, 2012·American Journal of Physiology. Endocrinology and Metabolism·Maarten R SoetersJohannes A Romijn
Jun 19, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Servane F BernardRené Groscolas
Sep 18, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Grant GreavesJonathan P Little
Oct 20, 2020·Journal of Agricultural and Food Chemistry·Tatsuya FushimiTakeshi Bamba

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