PMID: 9534945Apr 16, 1998Paper

Role of fatty acid binding protein on hepatic palmitate uptake

Canadian Journal of Physiology and Pharmacology
Frank J BurczynskiG Q Wang

Abstract

Expression of hepatic fatty acid binding protein (FABP) mRNA is regulated by growth hormone. In the absence of growth hormone, there is a 60% reduction in FABP mRNA levels (S.A. Berry, J.-B Yoon, U. List, and S. Seelig. J. Am. Coll. Nutr. 12:638-642. 1995). Previous work in our laboratory focused on the role of extracellular binding proteins in the hepatic uptake of long chain fatty acids. In the present study we were interested to determine the role of FABP in the transmembrane flux of long chain fatty acids. Using hepatocyte monolayers from control (n = 9) and hypophysectomized (n = 6) rats, we investigated the uptake of [3H]palmitate in the presence and absence of albumin. In the absence of albumin, total hepatocyte [3H]palmitate clearance rates from control (17.2 +/- 1.5 microL.mg-1 protein.s-1; mean +/- SEM; n = 9) and hypophysectomized (15.5 +/- 2.1 microL.mg-1 protein.s-1; n = 6) animals were similar (p > 0.05). In the presence of 2 microM albumin the total [3H]palmitate clearance rate from control hepatocytes (1.63 +/- 0.11 microL.mg-1 protein.s-1; n = 9) was significantly larger (40%) than from hepatocytes obtained from hypophysectomized (0.97 +/- 0.15 microL.mg-1 protein.s-1; n = 6; p < 0.01) animals. SDS-PAGE electro...Continue Reading

References

Jun 15, 1990·Experientia·R M KaikausR K Ockner
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·W StremmelP D Berk

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Citations

Apr 6, 1999·Journal of Hepatology·F J BurczynskiB Rosser
Jun 17, 2000·Trends in Endocrinology and Metabolism : TEM·A V Hertzel, D A Bernlohr
Jun 12, 2010·The Journal of Nutritional Biochemistry·Barbara P AtshavesFriedhelm Schroeder
Aug 25, 2004·The Journal of Pharmacy and Pharmacology·G Rajaraman, F J Burczynski
Feb 5, 2005·American Journal of Physiology. Cell Physiology·Barbara P AtshavesFriedhelm Schroeder

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