Role of FDG-PET in the definition of involved-field radiation therapy and management for pediatric Hodgkin's lymphoma

International Journal of Radiation Oncology, Biology, Physics
Virginia Lang RobertsonNatia Esiashvili

Abstract

To evaluate positron emission tomography-computed tomography (PET-CT) influences in involved-field radiation therapy (IFRT) field design in pediatric Hodgkin's lymphoma (HL). From June 2003 to February 2008, 30 pediatric HL patients were treated at Children's Healthcare of Atlanta (CHOA) and Emory University Department of Radiation Oncology with both chemotherapy and IFRT. Diagnostic contrast-enhanced CT and PET-CT were coregistered using image fusion software. Both were reviewed for all potential sites of involvement and correlated to determine concordance and discordance. They were used in IFRT planning to determine the influence of PET-CT on target volumes and field design. There were 546 regions analyzed by both PET and CT modalities. Image sets were concordant in 468 regions and discordant in 78, yielding 86% concordance overall. Analysis by weighted κ statistic showed "intermediate to good" fit overall and for nodal sites, but "poor" agreement for extranodal sites. If discordant, a site was most likely PET+/CT-. Integration of PET information caused a change in staging in 15 (50%) patients, 7 upstaged and 8 downstaged. The IFRT volumes were adjusted on the basis of initial PET-CT finding in 21 (70%) patients, with 32 site...Continue Reading

References

Oct 1, 1971·The Journal of Pediatrics·K A StarlingD J Fernbach
Jan 25, 2002·European Journal of Nuclear Medicine and Molecular Imaging·H W YeungY E Erdi
Aug 23, 2002·European Journal of Nuclear Medicine and Molecular Imaging·F MontraversJ N Talbot
Apr 30, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Christiaan SchiepersJohannes Czernin
Aug 4, 2004·European Journal of Nuclear Medicine and Molecular Imaging·E A WegnerM J O'Doherty
Jan 18, 2005·Pediatric Radiology·Sue C KasteMelissa M Hudson
Jun 28, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N G MikhaeelA R Timothy
Apr 20, 2006·Pediatric Radiology·Miguel Hernandez-PampaloniAbass Alavi
Jun 15, 2006·Journal of Pediatric Hematology/oncology·Melissa M RhodesSadhna Shankar
Jul 18, 2006·Journal of Computer Assisted Tomography·Elka MillerEinat Even-Sapir
Aug 17, 2006·Journal of Pediatric Hematology/oncology·Christian FurthHolger Amthauer
Oct 24, 2006·Annals of the New York Academy of Sciences·M LöfflerK-P Zimmer
Apr 23, 2008·Pediatric Blood & Cancer·Melissa Hines-ThomasMonika L Metzger
Jun 14, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R L ElstromR K J Brown
Mar 20, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wolfgang DörffelGünther Schellong

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Citations

Nov 2, 2018·The British Journal of Radiology·Greg ChambersAndrew Scarsbrook
Aug 10, 2011·Pediatric Blood & Cancer·Arnold C PaulinoStephen Chiang
Jun 27, 2018·Nuclear Medicine and Molecular Imaging·Jeong Won Lee, Sang Mi Lee
Aug 3, 2011·Radiologic Clinics of North America·R Paul GuillermanBruce R Parker

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