Role of ferroptosis in hepatocellular carcinoma.

Journal of Cancer Research and Clinical Oncology
Jianhua NieTongsen Zheng

Abstract

Hepatocellular carcinoma (HCC) is a complicated disease with low survival rate due to frequent recurrence and the lack of efficient therapies. For advanced HCC, sorafenib, as the only approved first-line drug for HCC, improves the survival to some extent, but depressingly with severe adverse effects and emerging resistance conditions, which cause a poor prognosis. Ferroptosis is a new recognized way of non-apoptosis-regulated cell death, characterized by the iron-dependent accumulation of lipid hydroperoxides, showing a tremendous promising in the therapy of cancer, especially in HCC. To provide ideas for the diagnosis and treatment of HCC, we summarized the role of ferroptosis in HCC. The relevant literature from PubMed is reviewed in this article. Interestingly enough, investigators have found sorafenib can induce ferroptosis in HCC. Moreover, recent researches reported increasing pathways and mechanisms related to ferroptosis in HCC such as TP53 and Rb, and strategies to improve sorafenib resistance by targeting ferroptosis. In addition, other drugs were reported to induce ferroptosis in HCC such as erastin and showed good efficacy in vivo and in vitro. In this review, we summarize pathways and mechanisms of ferroptosis in H...Continue Reading

References

Jul 31, 1996·Biochimica Et Biophysica Acta·P M Harrison, P Arosio
Sep 15, 2007·Gastroenterology·Christopher N MayhewErik S Knudsen
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Jan 15, 2009·Nature Reviews. Cancer·Erik S Knudsen, Karen E Knudsen
May 29, 2012·Cell·Scott J DixonBrent R Stockwell
Jan 9, 2013·Annual Review of Pharmacology and Toxicology·Qiang Ma
Mar 19, 2013·International Journal of Cancer. Journal International Du Cancer·Christophe LouandreAntoine Galmiche
May 15, 2013·Trends in Pharmacological Sciences·Takafumi SuzukiMasayuki Yamamoto
Mar 1, 2009·Expert Review of Clinical Pharmacology·Chiun HsuAnn Lii Cheng
Jan 21, 2014·Cell·Wan Seok YangBrent R Stockwell
Nov 18, 2014·Nature Cell Biology·Jose Pedro Friedmann AngeliMarcus Conrad
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Sep 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaofang SunDaolin Tang
Mar 15, 2016·Cell Chemical Biology·Wulf Tonnus, Andreas Linkermann
Mar 26, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaofang SunDaolin Tang
Apr 3, 2016·Biochemical and Biophysical Research Communications·Yangchun XieDaolin Tang
May 18, 2016·Neurobiology of Disease·Bruce Do VanJean-Christophe Devedjian
Jun 2, 2016·Autophagy·Wen HouDaolin Tang
Aug 12, 2016·Biochemical and Biophysical Research Communications·Hua YuanDaolin Tang
Oct 30, 2016·Biochemical and Biophysical Research Communications·Ding WangDaolin Tang
Jan 29, 2017·Cancer Research·Shan ZhuDaolin Tang
May 13, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jipeng GuoGang Wu
Aug 2, 2017·Biochemical and Biophysical Research Communications·Tao BaiYuling Sun
Aug 17, 2017·Cell Reports·Yangchun XieDaolin Tang
Nov 18, 2017·Neoplasia : an International Journal for Oncology Research·Shihui HaoMin Shi
Nov 24, 2017·Nature·Samantha W AlvarezRichard Possemato

❮ Previous
Next ❯

Citations

Jan 22, 2020·Journal of Cellular Physiology·Tao BaiYuling Sun
Jun 14, 2020·Signal Transduction and Targeted Therapy·Weiwei TangXuehao Wang
Jul 2, 2020·OncoTargets and Therapy·Yuechen ZhaoYan Jiao
Mar 31, 2019·Journal of Hematology & Oncology·Yanhua MouBin Li
Feb 6, 2020·Cell Death & Disease·Jie LiGang Wang
Jul 16, 2020·International Journal of Molecular Sciences·Martina Maria CapellettiKatell Peoc'h
Jan 11, 2020·Frontiers in Oncology·Hai-Hong ZhouXiao-Jian Yan
Sep 19, 2020·Apoptosis : an International Journal on Programmed Cell Death·Ying WangQianming Chen
Jul 16, 2020·Biomarker Research·Zhouxiao LiWeiwei Tang
Oct 8, 2020·Biomarker Research·Sipeng ZuoLinna Lu
Feb 13, 2021·Oxidative Medicine and Cellular Longevity·Yue ChengXiaojing Liu
Mar 19, 2021·Cell Death & Disease·Shu XuShenghong Zhang
Jul 17, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Azmi KhanAmrita Srivastava
Apr 2, 2021·Basic and Clinical Andrology·Erfaneh ShayganniaKazem Parivar
Apr 2, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Haiyan WangYongguang Tao
May 28, 2021·Veterinary Pathology·Sara Francesca SantagostinoEnrico Radaelli
Jul 13, 2021·European Journal of Pharmacology·Min JiaYulong Chen
Sep 21, 2021·The FEBS Journal·Keisuke HinoSohji Nishina

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cancer Metabolic Reprogramming

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cancer Metabolic Reprogramming (Keystone)

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.