Role of Fgf10 in cell proliferation in white adipose tissue

Molecular and Cellular Endocrinology
Morichika KonishiNobuyuki Itoh

Abstract

The development of white adipose tissue (WAT) involves adipogenesis and cell proliferation. Although the adipogenesis has been well studied, the cell proliferation has not. Therefore, we examined the mechanism of the proliferation by analyzing Fgf10(-/-) mouse embryonic WAT, in which adipogenesis and proliferation were severely impaired. D-type cyclin expression and retinoblastoma family protein phosphorylation essential for cell proliferation were examined in WAT. Both cyclin D2 expression and p130 phosphorylation were impaired in the Fgf10(-/-) WAT. In mouse embryonic fibroblasts, Fgf10 stimulated cyclin D2 expression and p130 phosphorylation, which were inhibited by an inhibitor of the Ras/MAPK pathway. These results suggest that Fgf10 stimulates cell proliferation in WAT through the Ras/MAPK pathway followed by the cyclin D2-dependent phosphorylation of p130. In contrast, expression but not phosphorylation of pRb was impaired in the Fgf10(-/-) WAT. As pRb is essential for adipogenesis, Fgf10 might play a role in adipogenesis by inducing its expression.

References

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Citations

Apr 9, 2009·Biochemical and Biophysical Research Communications·Ikuo KimuraMasafumi Fujimoto
Apr 9, 2008·Molecular and Cellular Endocrinology·Morichika KonishiNobuyuki Itoh
Jan 7, 2010·The FEBS Journal·Akira SuwaIchiro Aramori
Oct 16, 2015·Seminars in Cell & Developmental Biology·Elie El AghaSaverio Bellusci
Jul 13, 2016·Development·Eri ShibataAtsushi Kawakami
Jan 17, 2019·Current Drug Targets·Hassan Dianat-Moghadam, Ladan Teimoori-Toolabi
Jul 4, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen E McGowan, Diann M McCoy
Jan 7, 2017·Science·Maksim V PlikusGeorge Cotsarelis
Nov 25, 2011·Expert Review of Clinical Pharmacology·Xiaocong FangXiangdong Wang
Nov 20, 2019·Nature Metabolism·Oliver HahnLinda Partridge
Jun 15, 2021·Frontiers in Cell and Developmental Biology·Yu-Qing LvJin-San Zhang

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