Role of FGF23 in vitamin D and phosphate metabolism: implications in chronic kidney disease.

Experimental Cell Research
L Darryl Quarles

Abstract

FGF23 is a bone-derived hormone that regulates systemic phosphate homeostasis, vitamin D metabolism and α-Klotho expression through a novel bone-kidney axis. FGF23 inhibits renal tubular reabsorption of phosphate through mechanisms independent of PTH as well as reduces circulating 1, 25(OH)(2)D through its dual effects to suppress Cyp27b1 production and to stimulate Cyp24 catabolism of 1,25(OH)(2)D. 1,25(OH)(2)D and other factors regulating bone remodeling/mineralization are the major physiological regulators of FGF23 expression. FGF23 also suppresses the gene transcription of α-klotho by the kidney, which exists as a membrane and soluble protein. Membrane Klotho acts as a coreceptor for and dictates organ specificity of FGF23, whereas soluble Klotho act as an endocrine factor that regulates activity of cell surface glycoproteins and receptors in multiple tissues. Elevated FGF23 levels are responsible for several hereditary and acquired hypophosphatemic rickets disorders. FGF23 and Klotho deficiency have similar phenotypes characterized by hyperphosphatemia, elevated 1,25(OH)(2)D and tumoral calcinosis. FGF23 levels progressively increase during chronic kidney disease (CKD). FGF23 has been proposed to be the initial adaptive re...Continue Reading

References

Jun 25, 1996·Biochemistry·M J BeckmanH F DeLuca
Feb 13, 2001·Biochemical and Biophysical Research Communications·N KohY Nabeshima
May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·T ShimadaT Yamashita
Dec 12, 2001·Kidney International·K E WhiteM J Econs
Jan 11, 2002·The New England Journal of Medicine·Eileen M ShoreFrederick S Kaplan
Jul 10, 2002·Current Opinion in Nephrology and Hypertension·Seiji Fukumoto, Takeyoshi Yamashita
Jul 12, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Thomas J WeberL Darryl Quarles
Jul 23, 2003·The Journal of Biological Chemistry·Shiguang LiuL Darryl Quarles
Apr 17, 2004·Kidney International·Yasuo ImanishiYoshiki Nishizawa
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Geoffrey A BlockGlenn M Chertow
Aug 11, 2004·Circulation·Toshifumi ShimadaTsutomu Imaizumi
Aug 28, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tetsuhiko SatoMasafumi Fukagawa
Nov 16, 2004·Bone·Michiko MiramsAnne E Nelson
Dec 8, 2004·Matrix Biology : Journal of the International Society for Matrix Biology·Despina SitaraBeate Lanske
Dec 23, 2004·The Journal of Clinical Endocrinology and Metabolism·Serge L FerrariRené Rizzoli
May 27, 2005·Journal of the American Society of Nephrology : JASN·Orlando GutierrezMyles Wolf
Jul 7, 2005·American Journal of Physiology. Renal Physiology·Takashi ShimadaTakeyoshi Yamashita
Jul 21, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mohammed S RazzaqueBeate Lanske
Dec 13, 2005·Life Sciences·Keisuke KobayashiYoshiki Nishizawa
Dec 31, 2005·European Journal of Endocrinology·Keisuke KobayashiYoshiki Nishizawa
Jan 27, 2006·The Journal of Biological Chemistry·Hiroshi KurosuMakoto Kuro-o
Feb 2, 2006·American Journal of Physiology. Endocrinology and Metabolism·Shiguang LiuL Darryl Quarles
Apr 7, 2006·Journal of the American Society of Nephrology : JASN·Shiguang LiuL Darryl Quarles
Jun 1, 2006·The Journal of Clinical Endocrinology and Metabolism·Diana M AntoniucciAnthony A Portale
Jul 28, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sherri -Ann M BurnettJoel S Finkelstein
Oct 6, 2006·Kidney International·F TentoriUNKNOWN Medical Directors of Dialysis Clinic Inc
Jan 9, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lourdes CraverElvira Fernández
May 15, 2007·Journal of the American Society of Nephrology : JASN·Shiguang Liu, L Darryl Quarles
Jul 28, 2007·Journal of the American Society of Nephrology : JASN·Danilo FliserPeter Riegler
Sep 15, 2007·Journal of the American Society of Nephrology : JASN·Takehisa KawataYoshiki Nishizawa
Nov 10, 2007·The Journal of Clinical Investigation·Iddo Z Ben-DovJustin Silver
Aug 9, 2008·The New England Journal of Medicine·Orlando M GutiérrezMyles Wolf

❮ Previous
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Citations

Oct 30, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Csaba P Kovesdy
Apr 30, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Csaba P Kovesdy, Leigh Darryl Quarles
Sep 10, 2014·Journal of Endocrinological Investigation·A BianM C Hu
Jan 1, 2013·Bone Research·John S AdamsPhilip T Liu
Mar 9, 2013·Frontiers of Medicine·Eryuan Liao
Aug 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gunnar H HeineDanilo Fliser
Jan 4, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·María C IzquierdoAlberto Ortiz
Oct 16, 2013·Molecular Membrane Biology·Miribane Dërmaku-SopjaniMentor Sopjani
Jan 20, 2016·The Journal of Clinical Investigation·Xiuying BaiAndrew C Karaplis
Apr 16, 2013·Joint, Bone, Spine : Revue Du Rhumatisme·Linda IchchouClaude-Laurent Benhamou
Mar 8, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kamilla Nawrot-WawrzyniakNadja Fratzl-Zelman
Mar 8, 2013·Seminars in Nephrology·Cortney Bosworth, Ian H de Boer
Dec 18, 2015·BBA Clinical·Marzia PasqualiSandro Mazzaferro
Jun 17, 2014·Critical Care Medicine·Narat SrivaliWonngarm Kittanamongkolchai
Apr 29, 2015·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Tetsuya OgawaKosaku Nitta
Oct 23, 2012·Nutrition·Michael J Glade
May 13, 2014·Journal of Magnetic Resonance Imaging : JMRI·Mark S ShiroishiMeng Law
Oct 26, 2013·Journal of Diabetes Research·Xin JiangYaqin Qu
Aug 1, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Priscilla GrossZiad A Massy
Feb 5, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Yosuke NakayamaSeiya Okuda
Apr 1, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Zengliu SuYusheng Zhu
Apr 24, 2015·Critical Care : the Official Journal of the Critical Care Forum·Timo SpeerMatthias Klingele
Mar 26, 2015·Ageing Research Reviews·Camille TagliaferriVéronique Coxam
Feb 7, 2015·International Journal of Oral Science·Yu-Chen Guo, Quan Yuan
Apr 28, 2016·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Laura Salanova VillanuevaEsther Ortega Junco
Jun 18, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Anke DoyonUNKNOWN 4C Study Consortium
Jul 9, 2016·Vascular Pharmacology·Cristina Vassalle, Annamaria Mazzone
Oct 30, 2016·Bone Research·Vaishali VeldurthySylvia Christakos
Oct 25, 2016·Transplantation·Chethan Puttarajappa, Sundaram Hariharan
Oct 10, 2013·Food & Nutrition Research·Christel Lamberg-AllardtLaufey Steingrimsdottir
Feb 4, 2016·JPEN. Journal of Parenteral and Enteral Nutrition·Tiffany M N OteroSadeq A Quraishi
Oct 21, 2016·Medicine and Science in Sports and Exercise·Daniel J OwensGraeme L Close
Feb 17, 2017·Case Reports in Neurology·Masahiro OkazakiSusumu Kusunoki
Feb 19, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nadja Fratzl-ZelmanOuti Mäkitie
May 5, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·N S ClaytonE P Carter

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