PMID: 9423837Jan 10, 1998Paper

Role of flagella in pathogenesis of Pseudomonas aeruginosa pulmonary infection

Infection and Immunity
M FeldmanA Prince

Abstract

Pseudomonas aeruginosa strains are opportunistic pathogens associated with infections in immunocompromised hosts and patients with cystic fibrosis. Like many other mucosal pathogens, P. aeruginosa cells express flagella which provide motility and chemotaxis toward preferred substrates but also provide a ligand for clearance by phagocytic cells. We tested the role of flagella in the initial stages of respiratory tract infection by comparing the virulence of fliC mutants in a neonatal mouse model of pneumonia. In the absence of fliC, there was no mortality, compared with 30% mortality attributed to the parental strain PAK or 15% mortality associated with infection due to a pilA mutant PAK/NP (P < 0.0001). The fliC mutants caused pneumonia in only 25% of the mice inoculated, regardless of whether there was expression of the pilus, whereas the parental strain was associated with an 80% rate of pneumonia. Histopathological studies demonstrated that the fliC mutants caused very focal inflammation and that the organisms did not spread through the lungs as seen in infection due to either PAK or PAK/NP. Purified flagellin elicited an intense inflammatory response in the mouse lung. 125I-labeled flagellin bound to the glycolipids GM1 and...Continue Reading

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Citations

Jun 23, 1999·The Plant Journal : for Cell and Molecular Biology·L Gómez-GómezT Boller
Aug 20, 2002·The Journal of Biological Chemistry·Meghan A Donnelly, Theodore S Steiner
Dec 6, 2003·American Journal of Respiratory Cell and Molecular Biology·Amanda MuirAlice Prince
Apr 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Matthew C WolfgangStephen Lory
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Oct 27, 2004·Infection and Immunity·Anna N Honko, Steven B Mizel

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