Role of free radicals in pulmonary thromboembolism in mice

Thrombosis Research
M DikshitR C Srimal

Abstract

Involvement of free radicals and their scavenging enzymes in mice pulmonary thromboembolism, induced by intravenous infusion of collagen and adrenaline, has been studied. Malonaldehyde (MDA) and activities of xanthine oxidase (XO), catalase (CAT) and superoxide dismutase (SOD) were estimated in platelets, heart and lung homogenates. MDA increased in all the tissues sharply, while animals showed 70-80% thrombocytopenia. Xanthine oxidase activity in these animals increase significantly in heart. However, increased SOD activity and decreased catalase activity was observed in platelets. Intravenous administration of superoxide dismutase (5 mg/kg), catalase (5 mg/kg) and mannitol (200 mg/kg) protected the mice against pulmonary thromboembolism. The importance of free radicals in mice pulmonary thromboembolism has been demonstrated.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 1, 1975·Annual Review of Biochemistry·I Fridovich
Jun 15, 1989·Thrombosis Research·R SrivastavaR C Srimal
Apr 15, 1987·Thrombosis Research·M DikshitR C Srimal
Sep 1, 1985·Basic Research in Cardiology·E RöthB Matkovics
Nov 1, 1985·Thrombosis Research·R SrivastavaB N Dhawan
Jan 1, 1983·Annual Review of Pharmacology and Toxicology·I Fridovich

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Citations

Nov 18, 2006·Journal of Thrombosis and Thrombolysis·Diana MühlJános Lantos
Nov 1, 1994·Free Radical Biology & Medicine·R KumariR C Srimal
Oct 7, 2008·Basic & Clinical Pharmacology & Toxicology·Carlos A Dias-JuniorJose E Tanus-Santos
Jan 6, 2005·Nitric Oxide : Biology and Chemistry·Debora Cristine Souza-CostaJose Eduardo Tanus-Santos
May 1, 1992·Thrombosis Research·M DikshitR C Srimal
Jan 1, 1993·Thrombosis Research·R KumariR C Srimal
May 3, 2006·International Journal of Cardiology·Geisa M FortunaJose E Tanus-Santos
Oct 29, 2005·European Journal of Pharmacology·Allethea R Souza-SilvaJose E Tanus-Santos
Jan 1, 1992·Platelets·J J Belch
May 1, 1995·Redox Report : Communications in Free Radical Research·R KumariM Dikshit
Jun 25, 2005·Anesthesia and Analgesia·Carlos A Dias-JuniorJose E Tanus-Santos
Jul 1, 2011·Molecular and Cellular Biochemistry·Aline A da CunhaAngela T S Wyse

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