Role of frontal white matter and corpus callosum on social function in schizophrenia

Schizophrenia Research
Daisuke KoshiyamaRyota Hashimoto

Abstract

Patients with schizophrenia show severe impairment in social function and have difficulty in their daily social life. Although a recent large-scale multicenter study revealed alterations in white matter microstructures, the association between these anatomical changes and social dysfunction in schizophrenia remains unknown. Therefore, we investigated the association between the white matter integrity of regions of interest and social function in schizophrenia. A total of 149 patients with schizophrenia and 602 healthy comparison subjects (HCS) underwent DTI and completed the Picture Arrangement subtest of the Wechsler Adult Intelligence Scale-Third Edition and the Finance subscale of the University of California, San Diego, Performance-Based Skills Assessment Brief, as social indices of interest. The fractional anisotropy (FA) in the anterior corona radiata and corpus callosum was significantly lower in patients than in HCS, and the radial diffusivity (RD) in the anterior corona radiata and corpus callosum was significantly higher in patients. The Picture Arrangement and Finance scores were both significantly impaired in patients. The effect of the FA of the right anterior corona radiata on the Finance score and the Picture Arr...Continue Reading

Citations

Dec 4, 2019·Psychiatry and Clinical Neurosciences·Yuka YasudaRyota Hashimoto
Sep 30, 2020·Development·Noelia S De León ReyesMarta Nieto
Dec 31, 2020·Cells·Ray Yueh Ku, Masaaki Torii
Dec 20, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Daisuke KoshiyamaGregory A Light
Oct 29, 2020·Frontiers in Psychiatry·Kumiko Tanaka-KoshiyamaGregory A Light
May 1, 2020·Trends in Neurosciences·Katherine H Karlsgodt
Aug 25, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Daisuke KoshiyamaGregory A Light
Dec 11, 2020·Schizophrenia Research·Valentine BouetMichel Boulouard
Oct 22, 2020·Neuroscience Letters·Junya MatsumotoRyota Hashimoto
May 7, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·André S L M AntunesDaniel Martins-de-Souza
Dec 11, 2021·Clinical EEG and Neuroscience·Junya MatsumotoRyota Hashimoto
Oct 31, 2021·Psychiatry and Clinical Neurosciences·Toshiaki OnitsukaRyota Hashimoto
Jan 31, 2022·The Lancet Child & Adolescent Health·Mariesa CayJaymin Upadhyay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.