PMID: 6411993Jul 1, 1983Paper

Role of FSH and oestradiol-17 beta in the development of meiotic competence in rat oocytes

Journal of Steroid Biochemistry
S Bar-AmiA Tsafriri

Abstract

The ability of rat oocytes to resume meiotic maturation upon isolation ("meiotic competence") was shown to be abolished by hypophysectomy on day 15 post partum (p.p.). FSH (NIAMD-rat FSH-B-1; 10-20 micrograms/day), but not LH (NIAMD-oLH-21; 2-20 micrograms/day) was able to induce meiotic competence in rats hypophysectomixed on day 15 pp. Implantation of a capsule of oestradiol-17 beta, but not of progesterone or androstenedione, partially restored meiotic competence in hypophysectomized rats within 24 h of treatment. When inhibitors of steroidogenesis (aminoglutethimide, 17 beta-formamidoandrost-4-en-3-one, 1,4,6-androstatriene-3,17-dione or 4-hydroxy-4-androstene-3,17 dione) were coadministered with FSH they inhibited its effect on the development of meiotic competence. Furthermore, when oestradiol-17 beta was administered together with these inhibitors of steroidogenesis, the effect of FSH on the development of meiotic competence was not disturbed. These results strongly suggest that FSH, but not LH, is involved in the development of meiotic competence. Further, this action of FSH appears to be mediated, at least partially, by follicular oestrogen production.

References

Jan 1, 1979·The Journal of Clinical Endocrinology and Metabolism·B K TsangD T Armstrong
Mar 1, 1979·Journal of Reproduction and Fertility·D M Smith, D Y Tenney
Aug 1, 1975·Endocrinology·J P LouvetG T Ross
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Mar 1, 1982·Journal of Reproduction and Fertility·A TsafririS Bar-Ami

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Citations

Apr 20, 2005·Molecular and Cellular Endocrinology·A TsafririS H Pomerantz
Apr 21, 1992·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J O Ogunranti
Dec 1, 1985·Journal of in Vitro Fertilization and Embryo Transfer : IVF·P SundströmE Larsson
Sep 11, 2007·Trends in Endocrinology and Metabolism : TEM·Alex Tsafriri, Shmuel Motola
Sep 15, 1985·Biochemical Pharmacology·A M Brodie
Sep 1, 1989·Gamete Research·S A DanielR E Gore-Langton
Feb 1, 1986·Clinics in Endocrinology and Metabolism·A Tsafriri, S H Pomerantz
Jun 1, 1996·Molecular Reproduction and Development·J J EppigK Wigglesworth

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