Role of FTO in Adipocyte Development and Function: Recent Insights

International Journal of Endocrinology
Myrte Merkestein, Dyan Sellayah

Abstract

In 2007, FTO was identified as the first genome-wide association study (GWAS) gene associated with obesity in humans. Since then, various animal models have served to establish the mechanistic basis behind this association. Many earlier studies focussed on FTO's effects on food intake via central mechanisms. Emerging evidence, however, implicates adipose tissue development and function in the causal relationship between perturbations in FTO expression and obesity. The purpose of this mini review is to shed light on these new studies of FTO function in adipose tissue and present a clearer picture of its impact on obesity susceptibility.

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Citations

Sep 2, 2017·Journal of Biomedical Science·Yuling ZhouCraig S McLachlan
Apr 28, 2018·International Journal of Molecular Sciences·Kaiping DengPeihua You
Mar 21, 2019·Animal Models and Experimental Medicine·Hanifa J Abu-Toamih AtamniFuad A Iraqi
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Sep 29, 2018·International Journal of Molecular Sciences·Stephanie DiasSumaiya Adam
Sep 5, 2019·Frontiers in Cardiovascular Medicine·Esam S B SalemTakahisa Nakamura
Jul 10, 2021·Future Medicinal Chemistry·Shuting GaoJunbiao Chang

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Methods Mentioned

BETA
SGBS

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