Role of Functional IFNL4, IFNLR1, IFNA, IFNAR2 Polymorphisms in Hepatitis B virus-related liver disease in Han Chinese population

Journal of Viral Hepatitis
N MaD Liu

Abstract

Recent studies show that variants in some interferon genes together with interferon receptor genes are associated with the outcome of infectious diseases. We examined the association between the risk of hepatitis B virus (HBV)-related liver disease and the functional polymorphisms within IFNL4, IFNLR1, IFNA1, IFNA2, IFNA5 and IFNAR2 genes (14 loci in all) in a Han Chinese population. A total of 3128 people participated and were divided into 5 groups: healthy controls, natural clearance, chronic hepatitis B(CHB), liver cirrhosis and hepatocellular carcinoma (HCC). Significant associations were observed for 4 variants in IFNAR2, IFNLR1 with HBV infection, and IFNLR1-rs4649203 was associated with HBV recovery. Moreover, we demonstrated the clear relevance of 5 polymorphisms in IFNA1, IFNA2, IFNL4 with HCC. Three SNPs in IFNL4 gene may be important susceptible factors for the progression of HBV-related liver disease by trend chi-square test. The IFNL4 haplotype conformed by rs12971396_G, rs8113007_T and rs7248668A was more frequent in HCC than CHB and LC group. Three polymorphisms in the 5' region of the IFNL4 gene are associated with the progression of HBV-related liver disease. IFNA1- rs1831583 and IFNA2- rs649053 are associated ...Continue Reading

References

May 11, 1984·Nucleic Acids Research·J HiscottC Weissmann
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y CastelruizJ Prieto
Dec 7, 2002·Nature Immunology·Paul SheppardKevin M Klucher
Jan 16, 2003·The American Journal of Gastroenterology·Ziv Ben-AriTirza Klein
Mar 23, 2004·Annual Review of Immunology·Sidney PestkaPaul B Fisher
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Nov 18, 2004·Immunological Reviews·Sidney PestkaMark R Walter
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases
May 10, 2006·Cellular Microbiology·Akinori Takaoka, Hideyuki Yanai
Jun 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Angela J FrodshamAdrian V S Hill
Jul 5, 2006·Experimental & Molecular Medicine·Soo Cheon ChaeHun Taeg Chung
Jun 26, 2008·Nature Reviews. Immunology·Anthony J Sadler, Bryan R G Williams
Mar 26, 2009·BioFactors·Nina Ank, Søren R Paludan
Feb 10, 2011·Gut·Christabel KellyEleanor Barnes
Mar 16, 2011·The Journal of Infectious Diseases·Ping AnUNKNOWN HBV Study Consortium
Jul 12, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Qian CuiRong-Bin Yu
Jan 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Janett FischerThomas Berg
Apr 10, 2013·International Journal of Immunogenetics·I KimkongN Hirankarn
Jul 22, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Leonardo MottolaAlessandra Mangia
May 6, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Timokratis KaramitrosAngelos Hatzakis

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Citations

Sep 3, 2019·Frontiers in Genetics·Zhenhua ZhangMengji Lu
Dec 6, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jinghang XuZheng Zeng
Jun 13, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Gao XiaLiu Wenxuan
Jan 16, 2021·Journal of Leukocyte Biology·Nicole A de WeerdPaul J Hertzog
Oct 11, 2020·Immunology Letters·Walid Ben SelmaJalel Boukadida

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