Role of GABA and glutamate circuitry in hypothalamo-pituitary-adrenocortical stress integration

Annals of the New York Academy of Sciences
J P HermanHelmer Figueiredo

Abstract

GABA and glutamate play a major role in central integration of hypothalamo-pituitary-adrenocortical (HPA) stress responses. Recent work in our group has focused on mechanisms whereby GABAergic and glutamatergic circuits interact with parvocellular paraventricular nucleus (PVN) neurons controlling the HPA axis. GABAergic neurons in the bed nucleus of the stria terminalis, preoptic area, and hypothalamus can directly inhibit PVN outflow and thereby reduce ACTH secretion. In contrast, glutamate activates the HPA axis, presumably by way of hypothalamic and brainstem projections to the PVN. These inhibitory and excitatory PVN-projecting neurons are controlled by descending information from limbic forebrain structures, including glutamatergic neurons of the ventral subiculum, prefrontal cortex, and GABAergic cells from the amygdala and perhaps septum. Lesion studies indicate that the ventral subiculum and prefrontal cortex are involved in inhibition of HPA axis responses to psychogenic stimuli, whereas the amygdala is positioned to enhance hormone secretion by way of GABA-GABA disinhibitory connections. Thus, it seems the psychogenic responses to stress are gated by discrete sets of GABAergic neurons in the basal forebrain and hypoth...Continue Reading

References

Jan 1, 1975·Neuroendocrinology·G B Makara, E Stark
Jun 8, 1991·The Journal of Comparative Neurology·K M HurleyC B Saper
Jan 1, 1986·The American Journal of Physiology·S L Bealer
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·S FeldmanJ Weidenfeld
Sep 18, 1995·The Journal of Comparative Neurology·N S CanterasL W Swanson
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y I ShelineM W Vannier
Apr 22, 1996·The Journal of Comparative Neurology·W E CullinanS J Watson
Jan 1, 1996·Critical Reviews in Neurobiology·J P HermanW E Cullinan
Feb 1, 1997·Trends in Neurosciences·J P Herman, W E Cullinan
Jun 1, 1997·Journal of Neurophysiology·C BoudabaJ G Tasker
Dec 31, 1997·Brain Research. Brain Research Reviews·P Y Risold, L W Swanson
Dec 31, 1997·Brain Research. Brain Research Reviews·P Y Risold, L W Swanson
Jan 1, 1997·Journal of Neural Transmission·S Feldman, J Weidenfeld
Aug 28, 1998·Trends in Neurosciences·L W Swanson, G D Petrovich
Mar 29, 2000·Progress in Brain Research·P E SawchenkoA Ericsson
May 3, 2002·Neuroscience Research·Takeshi Kaneko, Fumino Fujiyama
Jul 13, 2002·The Journal of Comparative Neurology·Dana R ZieglerJames P Herman
Aug 24, 2002·The European Journal of Neuroscience·James P HermanJeffrey G Tasker
Sep 21, 2002·Journal of Endocrinological Investigation·E ArvatE Ghigo

❮ Previous
Next ❯

Citations

Mar 29, 2012·Psychopharmacology·Seong Shoon YoonChae Ha Yang
Aug 13, 2008·Brain Structure & Function·William E CullinanJames P Herman
Jul 21, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Eduardo E Benarroch
Dec 18, 2010·Bulletin of Experimental Biology and Medicine·V A EvseevI A Zaharova
Dec 17, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Georg M SingewaldKarl Ebner
Jul 28, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gordon B FeldJan Born
Mar 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alicia A Walf, Cheryl A Frye
Feb 23, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cynthia Neill EppersonChristian Grillon
Feb 22, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Younglim LeeAnantha Shekhar
Nov 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ilaria BertocchiCarola Eva
Nov 20, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joseph L HuntJoseph A Dimicco
Aug 30, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Salwa Al-NooriDianne P Figlewicz
Jan 7, 2009·Mediators of Inflammation·Alasdair George SutherlandJames D Hutchison
Apr 27, 2012·Advances in Pharmacological Sciences·Christiaan H Vinkers, Berend Olivier
Dec 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jhimly SarkarJamie Maguire
Oct 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael R BruchasCharles Chavkin
Jan 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aniko KorosiTallie Z Baram
Nov 15, 2013·Epilepsy Research·Kate K O'TooleJamie Maguire
Apr 25, 2012·Neurobiology of Disease·Thibault RenoirAnthony J Hannan
Mar 1, 2013·Journal of Neurophysiology·Hjalmar K TuressonDenis Pare
Jun 19, 2012·Experimental Physiology·Keiko UnnoMinoru Hoshino
Jan 17, 2012·Neuropharmacology·Eva MartisovaMaría Javier Ramírez
Jan 19, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M I CorderoC Sandi
May 31, 2011·Behavioural Brain Research·Sara B TaylorJames I Koenig
Jan 29, 2016·Neural Plasticity·Jamie Maguire, Istvan Mody
Dec 23, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Laverne Camille Melón, Jamie Maguire
Dec 17, 2009·Physiology & Behavior·Christiaan H VinkersBerend Olivier
Nov 26, 2009·Behavioural Brain Research·Kelly M BannaRonald E See
Jun 24, 2009·Frontiers in Neuroendocrinology·Michael B HennessyNorbert Sachser

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.