Role of GABA receptor complex in low dose lindane (HCH) induced neurotoxicity: neurobehavioural, neurochemical and electrophysiological studies

Drug and Chemical Toxicology
M AnandP K Seth

Abstract

Lindane is widely used as an insecticide and scabicide in mammals. High doses in chronic exposures caused hyperexcitability and convulsions and impaired motor activity involving GABA-ergic mechanism. To investigate the role of GABA/Benzodiazepine mechanism in the neurotoxicity of low doses of lindane, rats were administered 2, 3, or 5 mg/kg orally for 90 days and behavioural, electrophysiological, and neurochemical studies were conducted. The animals exposed to lindane exhibited increased geotaxis and decreased spontaneous drug-induced locomotor activity (which further potentiated by phenobarbitone and increased after leptazol). The EEG of the treated rats showed high voltage slow-wave activity (HVSA) patterns with occasional spindles (9-10 HZ-amplitude of 100 uv). A significant increase (p < 0.01) in GABA levels in cerebellum and significant increase in benzodiazepine receptors in cerebellar membrane measured by (3H)flunitrazepam binding were observed in the animals exposed to 3 and 5 mg lindane. The study suggests that low dose chronic exposure of lindane causes neurobehavioral, neurochemical, and electrophysiological effects involving GABA-ergic mechanism(s).

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Citations

Jan 5, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Dragan HrnčićOlivera Stanojlović
Oct 13, 2009·Chemico-biological Interactions·Anup Srivastava, T Shivanandappa
Jan 13, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shikha SrivastavaDevendra Parmar
Jul 7, 2007·Human & Experimental Toxicology·Virginia C Moser
Dec 18, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·E D Louis
May 12, 2006·Critical Reviews in Toxicology·E Mariussen, F Fonnum
Apr 18, 2008·Canadian Journal of Physiology and Pharmacology·Danijela VucevićOlivera Stanojlović
May 14, 2020·Ecotoxicology and Environmental Safety·Francisco A MartinsMatheus P Freitas

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