Role of GABA(B) receptors in learning and memory and neurological disorders

Neuroscience and Biobehavioral Reviews
Chelcie F Heaney, Jefferson W Kinney

Abstract

Although it is evident from the literature that altered GABAB receptor function does affect behavior, these results often do not correspond well. These differences could be due to the task protocol, animal strain, ligand concentration, or timing of administration utilized. Because several clinical populations exhibit learning and memory deficits in addition to altered markers of GABA and the GABAB receptor, it is important to determine whether altered GABAB receptor function is capable of contributing to the deficits. The aim of this review is to examine the effect of altered GABAB receptor function on synaptic plasticity as demonstrated by in vitro data, as well as the effects on performance in learning and memory tasks. Finally, data regarding altered GABA and GABAB receptor markers within clinical populations will be reviewed. Together, the data agree that proper functioning of GABAB receptors is crucial for numerous learning and memory tasks and that targeting this system via pharmaceuticals may benefit several clinical populations.

References

Jun 1, 1977·Journal of Comparative and Physiological Psychology·C T JohnsonP G Jenko
Nov 1, 1976·Journal of Comparative and Physiological Psychology·L E Jarrard
May 1, 1992·Science·J J Kim, M S Fanselow
Sep 1, 1991·Brain Research Bulletin·T Yamamoto, Y Fujimoto
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·C De Luca, M Massotti
May 31, 1990·Neuroscience Letters·D D MottH S Swartzwelder
Oct 1, 1989·Trends in Pharmacological Sciences·N Bowery
Aug 28, 1989·Brain Research·N C de LanerolleD D Spencer
Oct 1, 1989·Physiology & Behavior·C P Dokla, L J Thal
Jan 1, 1987·Psychopharmacology·H S SwartzwelderW A Wilson
Mar 3, 1987·Brain Research·D I KerrD R Curtis
Jan 1, 1988·Behavior Genetics·M Upchurch, J M Wehner
Oct 1, 1966·Journal of Comparative and Physiological Psychology·R J Douglas, A C Raphelson
Mar 1, 1969·Journal of Comparative and Physiological Psychology·D E Clody, P L Carlton
Apr 1, 1982·Journal of Comparative and Physiological Psychology·G Winocur
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Aug 18, 1995·Journal of Medicinal Chemistry·W FroestlR Bernasconi
Mar 1, 1995·Neuroscience Research·T YamamotoN Sakai
Nov 1, 1994·Behavioral and Neural Biology·V Luine, M Rodriguez
Nov 1, 1993·Trends in Pharmacological Sciences·H BittigerH R Olpe
Mar 1, 1994·Behavioral and Neural Biology·R W Stackman, T J Walsh

❮ Previous
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Citations

Sep 10, 2016·Journal of Applied Toxicology : JAT·Dietrich E LorkeGeorg A Petroianu
Aug 24, 2016·Scientific Reports·Thomas Hellesøe HolmKarin Lykke-Hartmann
Dec 8, 2016·Behavioural Pharmacology·Alfredo Meneses
Jul 25, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Crystal C Y Leung, Yung H Wong
Aug 22, 2017·International Journal of Molecular Sciences·Karan GovindpaniAndrea Kwakowsky
Mar 24, 2018·Annals of the New York Academy of Sciences·Irma Järvelä
May 30, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bahar SalavatiZafiris J Daskalakis
Nov 22, 2018·Journal of Neurology·Aurélien MaureilleJérôme Honnorat
Jun 5, 2019·Expert Opinion on Drug Metabolism & Toxicology·Emily E Hartwell, Henry R Kranzler
Jun 21, 2019·International Journal of Molecular Sciences·Masaru IshibashiAtsuo Fukuda
Jan 11, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jérémie NeastaSami Ben Hamida
Nov 9, 2018·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Jefferson W KinneyBruce T Lamb
Aug 9, 2018·Journal of Biomedical Science·Victor MarinhoSilmar Teixeira
Jan 11, 2020·Frontiers in Neuroanatomy·Sabrina BehuetKatrin Amunts
Jul 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Linn Samira Mari EvensethIngebrigt Sylte
Jul 7, 2017·Experimental Neurobiology·Yoo Sung Kim, Bo-Eun Yoon
Nov 14, 2018·Journal of Lipid Research·Anna N BukiyaAvia Rosenhouse-Dantsker
Mar 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Linn M EvensethIngebrigt Sylte
Apr 19, 2017·Behavioral and Brain Functions : BBF·Nan WuTao Sun
Sep 1, 2017·Annals of Neurology·Yongjin YooMurim Choi
Mar 29, 2016·Journal of Pineal Research·Haijie YuBertil Hille
May 6, 2020·International Journal of Molecular Sciences·Hana KubováPavel Mareš
Apr 8, 2020·International Journal of Molecular Sciences·Alejandro Martín-BelmonteRafael Luján
Mar 23, 2018·Acta Pharmacologica Sinica·Meng-Yi Xu, Albert H C Wong
Nov 11, 2020·Neuroscience and Biobehavioral Reviews·Salar VaseghiMohammad-Reza Zarrindast
Feb 9, 2021·Experimental Biology and Medicine·Sheila Ms Sears, Sandra J Hewett
Feb 13, 2021·Seminars in Cell & Developmental Biology·Joan Jiménez-Balado, Teal S Eich
Nov 25, 2020·Neurobiology of Aging·Arnold M SalazarJefferson W Kinney
May 15, 2021·Frontiers in Psychiatry·Ajay SarawagiAnant Bahadur Patel
Jun 3, 2021·Behavioral Sciences·Per Olav FolgerøLinn Heidi Stokkedal
Jul 20, 2021·Pflügers Archiv : European journal of physiology·Davide BassettiSergei Kirischuk
Aug 18, 2021·Learning & Memory·Julia CarboneSusanne Diekelmann
Aug 24, 2021·Frontiers in Cellular Neuroscience·Charlotte GustorffStefanie Endesfelder
Oct 17, 2021·Clinical Epigenetics·Qingqin S LiUNKNOWN Alzheimer’s Disease Neuroimaging Initiative (ADNI)

❮ Previous
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