PMID: 8611016Feb 13, 1996Paper

Role of gamma delta T cells in the regulation of mucosal IgA response and oral tolerance

Annals of the New York Academy of Sciences
K FujihashiH Kiyono

Abstract

In this short review, we first described experiments that show that prolonged oral immunization with a protein vaccine, such as DT, induced systemic unresponsiveness in the presence of antigen-specific mucosal IgA responses. Mucosal T cells, such as IEL, may play an important role for the maintenance of antigen-specific IgA responses because these T cells are able to respond to stimulation signals provided by antigen even when T-cell unresponsiveness was induced in systemic tissue, such as spleen of mice orally tolerized with the protein DT. Inasmuch as IEL contain a high frequency of gamma delta T cells, it was logical to postulate that mucosal gamma delta T cells are essential regulatory T cells for the induction of IgA responses in oral tolerance. To this end, our previous studies showed that adoptive transfer of mucosal gamma delta T cells from IEL of mice orally tolerized with SRBC to the recipient mice with systemic unresponsiveness to the same antigen resulted in the abrogation of unresponsiveness to Ig synthesis, including those of IgA isotype. In this regard, when the mucosal immune system of TCR-delta-/- and their control mice was examined, lower numbers of IgA antibody-producing cells were noted in TCR-delta-/- mice ...Continue Reading

References

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Citations

Oct 31, 1998·Current Opinion in Immunology·S Cobbold, H Waldmann
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·K FujihashiJ R McGhee
Oct 30, 2001·Acta Odontologica Scandinavica·K FujihashiJ R McGhee
Mar 10, 2016·Asian-Australasian Journal of Animal Sciences·Len Van TranAmrish Kumar Tyagi
Apr 16, 1998·The American Journal of Surgical Pathology·M M OttH K Müller-Hermelink
Feb 22, 2007·The Journal of Nutrition·Blaise CorthésyAnnick Mercenier

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