Role of gap junction in the expression of morphine-induced antinociception

European Journal of Pharmacology
Masami SuzukiTsutomu Suzuki

Abstract

The present study was undertaken to investigate whether gap junctional communication could be involved in morphine-induced antinociceptive response using blockers of the gap junctional channel, carbenoxolone and Gap27. Intrathecal pretreatment with either carbenoxolone or Gap27 caused a dose-dependent attenuation of morphine-induced antinociception. Furthermore, the dose-response line for morphine-induced antinociception was shifted to the right by 2.53-fold following intrathecal treatment with carbenoxolone. These findings suggest that gap-junctional-dependent communication in the mouse spinal cord may play, at least in part, a role in the expression of morphine-induced antinociception.

References

May 12, 2001·Science·M KamermansR Weiler
Jun 5, 2001·Nature Reviews. Neuroscience·M Galarreta, S Hestrin
Jul 11, 2002·Biological Chemistry·Klaus WilleckeGoran Söhl
Sep 25, 2003·Physiological Reviews·Juan C SaezEric C Beyer
Oct 31, 2003·Trends in Neurosciences·Michael V L BennettJuan C Sáez
Jan 13, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Minoru NaritaTsutomu Suzuki

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Citations

Oct 24, 2007·Peptides·Richard J Bodnar
Oct 6, 2011·Journal of Neuroscience Research·Ann WuGila Moalem-Taylor
Dec 3, 2014·European Journal of Pharmacology·Siamak BeheshtiMehdi Eivani

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