PMID: 11897971Mar 19, 2002Paper

Role of gas chromatography-mass spectrometry with negative ion chemical ionization in clinical and forensic toxicology, doping control, and biomonitoring

Therapeutic Drug Monitoring
H H Maurer

Abstract

This paper reviews procedures for the detection or quantification of drugs, pesticides, pollutants, and/or their metabolites relevant to clinical and forensic toxicology, doping control, or biomonitoring using gas chromatography-mass spectrometry with negative ion chemical ionization (GC-MS-NICI). Papers written in English between 1995 and 2000 are reviewed. Procedures are included for the analysis of the following halogen-containing or derivatizable compounds in common biosamples, such as whole blood, plasma, or urine, and in alternative matrices such as sweat, hair, bone, or muscle samples of humans or rats: benzodiazepines, cannabinoids, opioids, acetylsalicylic acid, angiotensin-converting enzyme inhibitors, ketoprofen, methylphenidate enantiomers, tegafur, zacopride, anabolic steroids, chlorophenols, chlorpyrifos, hexachlorocyclohexanes, organochlorines, and polychlorinated biphenyls. The principal information on each procedure is summarized in three tables to facilitate the selection of a method suitable for a specific analytic problem.

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Citations

Feb 13, 2004·Drug Discovery Today·András GuttmanJulia Khandurina
Nov 19, 2010·Bioanalysis·Jun HanChristoph H Borchers
Aug 10, 2011·Forensic Science International : Synergy·Flavia BadoudJean-Luc Veuthey
May 3, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ruut KaartamaMarko Lehtonen
Oct 30, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Per Magne UelandSteinar Hustad
Jul 1, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ya-Hsueh WuYan-Zin Chang
May 19, 2005·Toxicological Reviews·Robert J Flanagan
Dec 9, 2003·Applied Spectroscopy·Joe StuderJustin A Krouse
Jul 19, 2002·Journal of Mass Spectrometry : JMS
Mar 19, 2002·Therapeutic Drug Monitoring·Manfred R Moeller, Thomas Kraemer
Aug 26, 2021·Journal of Veterinary Pharmacology and Therapeutics·İsmet YılmazSelim Erdoğan

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