PMID: 590847Nov 1, 1977

Role of gastrointestinal hormones in the response to massive resection of the small bowel

Gut
A A D'sa, K D Buchanan

Abstract

Hypersecretion of gastric acid and accelerated intestinal transit are largely unexplained consequences of massive resection of the small bowel; several postulated humoral mechanisms remain unsubstantiated. The purpose of the study was to investigate the effects of 75% resection of the distal small bowel in dogs on circulating levels of a range of gastrointestinal hormones. Basal and meal-stimulated concentrations of insulin, secretin, gastrin, pancreatic glucagon, and total glucagon-like immunoreactivity (GLI) were measured by radioimmunoassay techniques. After resection, significant depletions of basal and stimulated total GLI (p less than 0.05 -- p less than 0.001) and a significant rise of stimulated gastrin (p less than 0.05) were discovered. These hormonal alterations may produce an important imbalance of humoral influences on gastrointestinal function. It is suggested that these changes may hold a key to the aetiology of the complications of massive resection of the small bowel.

References

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Citations

Jan 1, 1980·Diabetologia·J M Conlon
Feb 1, 1983·Digestive Diseases and Sciences·J H Landor
Mar 1, 1981·Digestive Diseases and Sciences·R JianJ C Rambaud
Apr 1, 1985·World Journal of Surgery·C RicourC Nihoul-Fekete
May 1, 1988·The Japanese Journal of Surgery·M SumikawaS Koga
Mar 1, 1978·Life Sciences·L I LarssonO Schaffalitzky de Muckadell
Apr 1, 2000·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J ChabertM Roche
Oct 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·M UchiyamaS Ohtani
Oct 1, 1982·Gut·H S BestermanS R Bloom
May 1, 1978·Postgraduate Medical Journal·A A Barros D'SaA D Roy
Sep 20, 1979·World Journal of Surgery·W C Meyers, R S Jones
Nov 1, 1994·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·J S Thompson, R F Harty
May 13, 1982·Nature·P KirkegaardJ Christiansen
Jul 1, 1979·The British Journal of Surgery·A A Barros D'Sa

Related Concepts

Canis familiaris
Gastric Juice
Gastrin
Enteric Hormones
Intestinal Motility
Glucagon
Novolin
Intestines, Small
Pancreatic Hormones
Secrepan

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